Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0224 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0224 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 17000 nM.hr | AUC (0-4 hrs) in BALB/c mouse at 50 mg/kg, po after 4 hrs | ChEMBL. | 15615512 |
AUC (ADMET) | = 17000 nM.hr | AUC (0-4 hrs) in BALB/c mouse at 50 mg/kg, po after 4 hrs | ChEMBL. | 15615512 |
Cmax (ADMET) | = 9600 nM | Cmax in BALB/c mouse at 50 mg/kg, po after 4 hrs | ChEMBL. | 15615512 |
Cmax (ADMET) | = 9600 nM | Cmax in BALB/c mouse at 50 mg/kg, po after 4 hrs | ChEMBL. | 15615512 |
Cp (ADMET) | = 1900 nM | Plasma concentration in BALB/c mouse at 50 mg/kg, po after 4 hrs | ChEMBL. | 15615512 |
Cp (ADMET) | = 1900 nM | Plasma concentration in BALB/c mouse at 50 mg/kg, po after 4 hrs | ChEMBL. | 15615512 |
IC50 (functional) | < 2 nM | Antiproliferative activity against human K562 cells after 72 hrs | ChEMBL. | 15615512 |
IC50 (functional) | < 2 nM | Antiproliferative activity against human K562 cells after 72 hrs | ChEMBL. | 15615512 |
IC50 (binding) | = 4 nM | In vitro inhibitory activity against recombinant p56 lck tyrosine kinase expressed as a His-tagged protein in insect cells | ChEMBL. | 15546730 |
IC50 (functional) | = 17 nM | In vivo inhibitory activity of the compound against proliferation of normal human peripheral blood T lymphocytes | ChEMBL. | 15546730 |
IC50 (functional) | = 82 nM | Antiproliferative activity against human PC3 cells after 72 hrs | ChEMBL. | 15615512 |
IC50 (functional) | = 82 nM | Antiproliferative activity against human PC3 cells after 72 hrs | ChEMBL. | 15615512 |
IC50 (functional) | = 170 nM | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs | ChEMBL. | 15615512 |
IC50 (functional) | = 170 nM | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs | ChEMBL. | 15615512 |
IC50 (functional) | = 270 nM | Antiproliferative activity against human WiDr cells after 72 hrs | ChEMBL. | 15615512 |
IC50 (functional) | = 270 nM | Antiproliferative activity against human WiDr cells after 72 hrs | ChEMBL. | 15615512 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15615512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.