Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | 0.0735 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0026 | 0.0026 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0026 | 0.0076 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0026 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0026 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.5763 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0437 | 0.5763 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.058 | 0.1716 |
Trichomonas vaginalis | set domain proteins, putative | 0.0252 | 0.3136 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0026 | 0.0026 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.027 | 0.3381 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0197 | 0.2348 | 0.2348 |
Brugia malayi | Pre-SET motif family protein | 0.0222 | 0.27 | 0.7987 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.1058 | 0.3129 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.5763 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0437 | 0.5763 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0735 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.3381 | 0.5867 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0222 | 0.27 | 0.4686 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.5763 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0045 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.1058 | 0.1836 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0197 | 0.2348 | 0.2348 |
Onchocerca volvulus | 0.0252 | 0.3136 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.058 | 0.1007 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.058 | 0.058 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0026 | 0.0045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.003 uM | Concentration required to inhibit cell proliferation in RPM18402 tumor cell line | ChEMBL. | 15482929 |
IC50 (functional) | = 0.003 uM | Concentration required to inhibit cell proliferation in P388 tumor cell line | ChEMBL. | 15482929 |
IC50 (functional) | = 0.003 uM | Concentration required to inhibit cell proliferation in KB3-1 tumor cell line | ChEMBL. | 15482929 |
IC50 (functional) | = 0.003 uM | Concentration required to inhibit cell proliferation in RPM18402 tumor cell line | ChEMBL. | 15482929 |
IC50 (functional) | = 0.003 uM | Concentration required to inhibit cell proliferation in P388 tumor cell line | ChEMBL. | 15482929 |
IC50 (functional) | = 0.003 uM | Concentration required to inhibit cell proliferation in KB3-1 tumor cell line | ChEMBL. | 15482929 |
IC50 (functional) | = 0.005 uM | Concentration required to inhibit cell proliferation in KBH5.0 tumor cell line; overexpress BCRP | ChEMBL. | 15482929 |
IC50 (functional) | = 0.005 uM | Concentration required to inhibit cell proliferation in KBH5.0 tumor cell line; overexpress BCRP | ChEMBL. | 15482929 |
IC50 (functional) | = 0.01 uM | Concentration required to inhibit cell proliferation in KBV-1 tumor cell line; overexpress MDR1 | ChEMBL. | 15482929 |
IC50 (functional) | = 0.01 uM | Concentration required to inhibit cell proliferation in KBV-1 tumor cell line; overexpress MDR1 | ChEMBL. | 15482929 |
IC50 (functional) | = 0.03 uM | Concentration required to inhibit cell proliferation in P388/CPT-45 tumor cell line; camptothecin resistant | ChEMBL. | 15482929 |
IC50 (functional) | = 0.9 uM | Concentration required to inhibit cell proliferation in CPT-K5 tumor cell line; camptothecin resistant | ChEMBL. | 15482929 |
IC50 (functional) | = 0.9 uM | Concentration required to inhibit cell proliferation in CPT-K5 tumor cell line; camptothecin resistant | ChEMBL. | 15482929 |
REC (binding) | = 0.7 | Relative effective concentration to cleave plasmid DNA with human topoisomerase I; compared to camptothecin=1 | ChEMBL. | 15482929 |
REC (binding) | = 0.7 | Relative effective concentration to cleave plasmid DNA with human topoisomerase I; compared to camptothecin=1 | ChEMBL. | 15482929 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15482929 | |
Homo sapiens | ChEMBL23 | 15482929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.