Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0732 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0732 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0732 | 1 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0732 | 1 | 1 |
Onchocerca volvulus | 0.0732 | 1 | 1 | |
Echinococcus granulosus | tissue type plasminogen activator | 0.0732 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0732 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0732 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0732 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0732 | 1 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0732 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.822 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.664 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.524 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.523 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.381 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.274 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.268 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.254 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.228 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.157 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.69 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | < 0.26 ug ml-1 | Inhibitory concentration required to produce cytotoxicity against VERO cells | ChEMBL. | 16005211 |
MIC (functional) | = 3.13 ug ml-1 | Minimum inhibitory concentration against Mycobacterium tuberculosis H37Rv pFPCA1 in green fluorescent protein microplate assay | ChEMBL. | 16005211 |
MIC (functional) | = 3.13 ug ml-1 | Minimum inhibitory concentration against Mycobacterium tuberculosis H37Rv pFPCA1 in green fluorescent protein microplate assay | ChEMBL. | 16005211 |
Selectivity (functional) | < 0.08 | Selectivity ratio for IC50 of VERO cells to that of MIC of Mycobacterium tuberculosis H37Rv | ChEMBL. | 16005211 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.