Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0498 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.0498 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0498 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.0498 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0498 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.5 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0498 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.5 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0498 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0498 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0498 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.5 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0498 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0498 | 0.5 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0498 | 0.5 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0498 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0498 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0498 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 25 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 25 nM | Binding affinity to ERbeta | ChEMBL. | 17459530 |
IC50 (binding) | = 210 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 210 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
Selectivity (binding) | = 8 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 8 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.