Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.05 uM | In vitro inhibitory concentration against Prostaglandin G/H synthase 1 in human whole blood assay | ChEMBL. | 15369392 |
IC50 (binding) | = 0.05 uM | In vitro inhibitory concentration against Prostaglandin G/H synthase 1 in human whole blood assay | ChEMBL. | 15369392 |
IC50 (binding) | = 0.05 uM | Inhibition of human platelet COX1 by whole blood assay | ChEMBL. | 24531199 |
IC50 (binding) | = 1.49 uM | In vitro inhibitory concentration against Prostaglandin G/H synthase 2 in human whole blood assay | ChEMBL. | 15369392 |
IC50 (binding) | = 1.49 uM | In vitro inhibitory concentration against Prostaglandin G/H synthase 2 in human whole blood assay | ChEMBL. | 15369392 |
IC50 (binding) | = 1.49 uM | Inhibition of human monocyte COX2 by whole blood assay | ChEMBL. | 24531199 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.