Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | outer membrane protein PmpD | 0.0072 | 0.5 | 0.5 |
Chlamydia trachomatis | outer membrane protein PmpC | 0.0072 | 0.5 | 0.5 |
Chlamydia trachomatis | outer membrane protein PmpB | 0.0072 | 0.5 | 0.5 |
Chlamydia trachomatis | outer membrane protein PmpF | 0.0072 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 12.6 uM | Concentration required to relax KCl induced rat aorta ring contractions by 50% upon incubation with the compound at 37 degree C for 90 mins | ChEMBL. | 16033278 |
IC50 (functional) | = 1.25 uM | Concentration required to inhibit insulin release in rat pancreatic islets by 50% upon incubation with the compound at 37 degree C for 90 mins | ChEMBL. | 16033278 |
Release (functional) | = 8.4 % | Percent residual insulin release in rat pancreatic islets upon incubation with the compound (10 uM) at 37 degree C for 90 mins | ChEMBL. | 16033278 |
Release (functional) | = 58.1 % | Percent residual insulin release in rat pancreatic islets upon incubation with the compound (1 uM) at 37 degree C for 90 mins | ChEMBL. | 16033278 |
Selectivity (functional) | = 10.1 | Ratio of EC50 required to relax KCl induced rat aorta ring contractions to that of IC50 required to inhibit insulin release in rat pancreatic islets | ChEMBL. | 16033278 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.