Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | transporter, putative | 0.0077 | 0.3578 | 1 |
Leishmania major | farnesyltransferase beta subunit | 0.0056 | 0.1209 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0089 | 0.4963 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.0056 | 0.1209 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0077 | 0.3578 | 1 |
Giardia lamblia | Prenyltransferase | 0.0056 | 0.1209 | 0.5 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0056 | 0.1209 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0052 | 0.0827 | 0.1666 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0056 | 0.1209 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0089 | 0.4963 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0061 | 0.1816 | 1 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0056 | 0.1209 | 0.2436 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0061 | 0.1816 | 1 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.0056 | 0.1209 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0082 | 0.4136 | 0.8334 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0056 | 0.1209 | 0.2436 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0082 | 0.4136 | 1 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.0056 | 0.1209 | 0.5 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0056 | 0.1209 | 0.5 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0077 | 0.3578 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0082 | 0.4136 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0134 | 1 | 1 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0056 | 0.1209 | 1 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0056 | 0.1209 | 0.5 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0056 | 0.1209 | 0.5 |
Trypanosoma brucei | lanosterol synthase | 0.0061 | 0.1816 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0045 | 0 | 0.5 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0061 | 0.1816 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0077 | 0.3578 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.25 uM | Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells | ChEMBL. | 15267235 |
IC50 (binding) | = 0.25 uM | Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells | ChEMBL. | 15267235 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.