Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3939 nM | Concentration required for the 50% inhibition of human stomach cancer (MKN45) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | = 3939 nM | Concentration required for the 50% inhibition of human stomach cancer (MKN45) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | = 8064 nM | Concentration required for the 50% inhibition of human uterine cancer (MESSA) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | = 8064 nM | Concentration required for the 50% inhibition of human uterine cancer (MESSA) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | = 8562 nM | Concentration required for the 50% inhibition of human lung caner (A549) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | = 8562 nM | Concentration required for the 50% inhibition of human lung caner (A549) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | > 10000 nM | Concentration required for the 50% inhibition of human breast cancer (MCF-7) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | > 10000 nM | Concentration required for the 50% inhibition of human stomach cancer (NUGC3) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | > 10000 nM | Concentration required for the 50% inhibition of human breast cancer (MCF-7) cell line growth | ChEMBL. | 15293996 |
IC50 (functional) | > 10000 nM | Concentration required for the 50% inhibition of human stomach cancer (NUGC3) cell line growth | ChEMBL. | 15293996 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15293996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.