Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | caspase 2 | 0.0367 | 0.2068 | 0.2068 |
Loa Loa (eye worm) | matrixin family protein | 0.0185 | 0.0258 | 0.0258 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0302 | 0.1422 | 0.1422 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0302 | 0.1422 | 0.1422 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.1165 | 1 | 1 |
Echinococcus granulosus | caspase 2 | 0.0367 | 0.2068 | 0.2068 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.1 | 0.8364 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0278 | 0.1184 | 0.1184 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.1165 | 1 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0307 | 0.147 | 0.147 |
Echinococcus multilocularis | caspase | 0.0302 | 0.1422 | 0.1422 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.1 | 0.8364 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0278 | 0.1184 | 0.1184 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.1165 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0208 | 0.0488 | 0.0488 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.1165 | 1 | 1 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.1165 | 1 | 0.5 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.1165 | 1 | 1 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.1165 | 1 | 1 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.1165 | 1 | 1 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.1 | 0.8364 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.1 | 0.8364 | 1 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.1 | 0.8364 | 1 |
Brugia malayi | Matrixin family protein | 0.0185 | 0.0258 | 0.0258 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0302 | 0.1422 | 0.1422 |
Schistosoma mansoni | hypothetical protein | 0.0208 | 0.0488 | 0.0488 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.1165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.2068 | 0.2068 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.1165 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0367 | 0.2068 | 0.2068 |
Onchocerca volvulus | 0.0208 | 0.0488 | 0.1946 | |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0208 | 0.0488 | 0.0488 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.1165 | 1 | 1 |
Echinococcus granulosus | caspase | 0.0302 | 0.1422 | 0.1422 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0208 | 0.0488 | 0.0488 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.036 | 0.1995 | 0.2334 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0488 | 0.0488 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.1165 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0367 | 0.2068 | 0.2068 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0302 | 0.1422 | 0.1422 |
Loa Loa (eye worm) | matrixin family protein | 0.017 | 0.0106 | 0.0106 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0367 | 0.2068 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP | = 2.896 | The octanol/water partition coefficient expressed in logarithmic form | ChEMBL. | 15990300 |
GI50 (functional) | NA 0 uM | Concentration required for 50% reduction of cellular net growth of HL60 human leukemia cells; na=no activity | ChEMBL. | 15990300 |
GI50 (functional) | NA 0 uM | Concentration required for 50% reduction of cellular net growth of MCF-7 human breast cancer cells | ChEMBL. | 15990300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.