Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | 0.0082 | 0.6869 | 0.6869 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0024 | 0.0212 | 0.0212 |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.011 | 1 | 0.5 |
Giardia lamblia | Cytidine deaminase | 0.011 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0024 | 0.0212 | 0.0212 |
Echinococcus multilocularis | cytidine deaminase | 0.011 | 1 | 1 |
Onchocerca volvulus | 0.011 | 1 | 1 | |
Trichomonas vaginalis | cytidine deaminase, putative | 0.011 | 1 | 1 |
Entamoeba histolytica | cytidine deaminase, putative | 0.011 | 1 | 0.5 |
Echinococcus granulosus | cytidine deaminase | 0.011 | 1 | 1 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.011 | 1 | 1 |
Trypanosoma cruzi | cytidine deaminase-like protein | 0.011 | 1 | 1 |
Trypanosoma cruzi | cytidine deaminase-like protein, putative | 0.011 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0024 | 0.0212 | 0.0212 |
Trypanosoma brucei | cytidine deaminase | 0.011 | 1 | 1 |
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.011 | 1 | 1 |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.011 | 1 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.0212 | 0.0212 |
Leishmania major | cytidine deaminase-like protein | 0.011 | 1 | 1 |
Mycobacterium ulcerans | cytidine deaminase | 0.011 | 1 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.6869 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0024 | 0.0212 | 0.0212 |
Onchocerca volvulus | 0.011 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 61 nM | Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independent measurements | ChEMBL. | 15950467 |
Ki (binding) | = 61 nM | Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independent measurements | ChEMBL. | 15950467 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.