Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.2041 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.2041 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.2041 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.2041 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.2041 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0883 | 0 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0883 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.2041 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.2041 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.2041 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.2041 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.2041 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.2041 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.2041 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.2041 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.2041 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.2041 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.2041 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.07 uM | Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16033270 |
Ki (binding) | = 0.7 uM | Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16033270 |
Ki (binding) | = 1.2 uM | Percent inhibition of [3H]ZM241,385 binding to human adenosine A2a receptor expressed in CHO cells at 10 uM | ChEMBL. | 16033270 |
Ki (binding) | = 1.2 uM | Percent inhibition of [3H]ZM241,385 binding to human adenosine A2a receptor expressed in CHO cells at 10 uM | ChEMBL. | 16033270 |
Ki (binding) | = 1.88 uM | Percent inhibition of [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16033270 |
Ki (binding) | = 1.88 uM | Percent inhibition of [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16033270 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.