Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Mus musculus | estrogen receptor 2 (beta) | Starlite/ChEMBL | References |
Mus musculus | estrogen receptor 1 (alpha) | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Rattus norvegicus | Estrogen receptor beta | Starlite/ChEMBL | References |
Rattus norvegicus | Estrogen receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | Estrogen receptor beta | 530 aa | 451 aa | 25.5 % |
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Onchocerca volvulus | Estrogen receptor beta | 530 aa | 430 aa | 24.9 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.5 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 9.5 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 20 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 20 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER beta expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 50 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 50 nM | Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 50 nM | Binding affinity to ERbeta | ChEMBL. | 17459530 |
IC50 (binding) | = 821 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 821 nM | Inhibition of [3H]-17-beta-estradiol binding to rat ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 902 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 902 nM | Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand | ChEMBL. | 15456246 |
IC50 (binding) | = 1335 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER alpha expressed in E. coli | ChEMBL. | 15456246 |
IC50 (binding) | = 1335 nM | Inhibition of [3H]-17-beta-estradiol binding to mouse ER alpha expressed in E. coli | ChEMBL. | 15456246 |
Selectivity (binding) | = 18 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 40 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 140 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 18 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 40 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Selectivity (binding) | = 140 | Selectivity fold for estrogen receptor beta over estrogen receptor alpha | ChEMBL. | 15456246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.