Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.0121 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0121 | 0 | 0.5 |
Onchocerca volvulus | 0.0121 | 0 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.017 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0121 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.017 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0121 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.017 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.017 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0121 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0121 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0121 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.017 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0121 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity in mice through seizures induced by subcutaneous pentylenetetrazol (scPTZ) tests after ip administration at a concentration of 300 mg/kg after 30 min; Inactive | ChEMBL. | 10753468 | |
Activity (functional) | Anticonvulsant activity in mice through seizures induced by maximal electroshock (MES) tests after ip administration at a concentration of 100 mg/kg after 30 min; Inactive | ChEMBL. | 10753468 | |
Activity (functional) | Anticonvulsant activity in mice through seizures induced by sc pentylenetetrazol (intraperitoneal administration at a concentration of 300 mg/kg after 4 hours; Inactive | ChEMBL. | 10753468 | |
Activity (functional) | Anticonvulsant activity in mice through seizures induced by maximal electroshock (MES) tests after ip administration at a concentration of 300 mg/kg after 4 hours; Active | ChEMBL. | 10753468 | |
Activity (functional) | Neurotoxicity of the compound was determined by rotorod test after intraperitoneal administration at a concentration of 300 mg/kg after 30 minutes; Inactive | ChEMBL. | 10753468 | |
Activity (functional) | Neurotoxicity determined by rotorod test after intraperitoneal administration at a concentration of 300 mg/kg after 4 hours; Inactive | ChEMBL. | 10753468 | |
Activity (functional) | 0 | Anticonvulsant activity in mice through seizures induced by maximal electroshock (MES) tests after ip administration at a concentration of 100 mg/kg after 30 min; Inactive | ChEMBL. | 10753468 |
Activity (functional) | 0 | Anticonvulsant activity in mice through seizures induced by maximal electroshock (MES) tests after ip administration at a concentration of 300 mg/kg after 4 hours; Active | ChEMBL. | 10753468 |
Activity (functional) | 0 | Anticonvulsant activity in mice through seizures induced by subcutaneous pentylenetetrazol (scPTZ) tests after ip administration at a concentration of 300 mg/kg after 30 min; Inactive | ChEMBL. | 10753468 |
Activity (functional) | 0 | Anticonvulsant activity in mice through seizures induced by sc pentylenetetrazol (intraperitoneal administration at a concentration of 300 mg/kg after 4 hours; Inactive | ChEMBL. | 10753468 |
Activity (functional) | 0 | Neurotoxicity of the compound was determined by rotorod test after intraperitoneal administration at a concentration of 300 mg/kg after 30 minutes; Inactive | ChEMBL. | 10753468 |
Activity (functional) | 0 | Neurotoxicity determined by rotorod test after intraperitoneal administration at a concentration of 300 mg/kg after 4 hours; Inactive | ChEMBL. | 10753468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.