Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | purine nucleoside transporter | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | 456 aa | 396 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Echinococcus granulosus | caspase | 0.0086 | 0.3854 | 0.3854 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0098 | 1 | 1 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0081 | 0.1226 | 0.1226 |
Echinococcus granulosus | equilibrative nucleoside transporter 3 | 0.0098 | 1 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Echinococcus multilocularis | caspase | 0.0086 | 0.3854 | 0.3854 |
Brugia malayi | hypothetical protein | 0.0098 | 1 | 1 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.0098 | 1 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0086 | 0.3854 | 0.3854 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0086 | 0.3854 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0086 | 0.3854 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Echinococcus multilocularis | equilibrative nucleoside transporter protein | 0.0098 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Entamoeba histolytica | nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.0098 | 1 | 1 |
Echinococcus granulosus | equilibrative nucleoside transporter | 0.0098 | 1 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0098 | 1 | 0.5 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0086 | 0.3854 | 0.3854 |
Giardia lamblia | Hypothetical protein | 0.0098 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 196 nM | Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane | ChEMBL. | 15481982 |
Ki (binding) | = 196 nM | Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane | ChEMBL. | 15481982 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.