Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclins | 0.0129 | 0.1382 | 0.1351 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0246 | 0.3497 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0263 | 0.3793 | 0.3799 |
Trichomonas vaginalis | cyclin B, putative | 0.0129 | 0.1382 | 0.5559 |
Echinococcus multilocularis | cyclins | 0.0129 | 0.1382 | 0.1351 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0246 | 0.3497 | 0.3474 |
Schistosoma mansoni | cyclins | 0.0129 | 0.1382 | 0.1351 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0246 | 0.3497 | 0.3479 |
Trichomonas vaginalis | cyclin B, putative | 0.0189 | 0.2458 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0246 | 0.3497 | 0.3474 |
Trichomonas vaginalis | cyclin A, putative | 0.0189 | 0.2458 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0054 | 0.0036 | 0.0036 |
Brugia malayi | protein C17H12.11 | 0.0233 | 0.3262 | 0.3243 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0263 | 0.3793 | 0.3771 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.3262 | 0.3267 |
Trichomonas vaginalis | cyclins, putative | 0.0189 | 0.2458 | 1 |
Echinococcus multilocularis | cyclins | 0.0129 | 0.1382 | 0.1351 |
Trichomonas vaginalis | cyclins, putative | 0.0129 | 0.1382 | 0.5559 |
Echinococcus multilocularis | cyclins | 0.0129 | 0.1382 | 0.1351 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0189 | 0.2458 | 0.6999 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0189 | 0.2458 | 0.2435 |
Loa Loa (eye worm) | GMP reductase | 0.0102 | 0.0913 | 0.0914 |
Echinococcus multilocularis | cyclins | 0.0129 | 0.1382 | 0.1351 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0054 | 0.0036 | 0.0036 |
Echinococcus granulosus | cyclin b3 | 0.0129 | 0.1382 | 0.1351 |
Echinococcus multilocularis | cyclins | 0.0129 | 0.1382 | 0.1351 |
Entamoeba histolytica | cyclin family protein | 0.0129 | 0.1382 | 0.5559 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0232 | 0.3234 | 0.8869 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0263 | 0.3793 | 0.3776 |
Leishmania major | guanosine monophosphate reductase | 0.0246 | 0.3497 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0189 | 0.2458 | 0.6999 |
Giardia lamblia | Hypothetical protein | 0.0129 | 0.1382 | 0.5559 |
Trichomonas vaginalis | cyclin D, putative | 0.0129 | 0.1382 | 0.5559 |
Schistosoma mansoni | protein kinase | 0.0275 | 0.4005 | 0.3984 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0246 | 0.3497 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0232 | 0.3234 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0189 | 0.2458 | 1 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0246 | 0.3497 | 0.3474 |
Trichomonas vaginalis | cyclins, putative | 0.0189 | 0.2458 | 1 |
Echinococcus granulosus | cyclins | 0.0129 | 0.1382 | 0.1351 |
Echinococcus granulosus | cyclins | 0.0129 | 0.1382 | 0.1351 |
Brugia malayi | hypothetical protein | 0.0233 | 0.3262 | 0.3243 |
Giardia lamblia | Cyclin A | 0.0129 | 0.1382 | 0.5559 |
Echinococcus granulosus | cyclin B | 0.0189 | 0.2458 | 0.2431 |
Trichomonas vaginalis | cyclins, putative | 0.0189 | 0.2458 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0189 | 0.2458 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0102 | 0.0913 | 0.0881 |
Leishmania major | cyclin | 0.0189 | 0.2458 | 0.6999 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0246 | 0.3497 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0189 | 0.2458 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0263 | 0.3793 | 0.3771 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0129 | 0.1382 | 0.5559 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0246 | 0.3497 | 0.5 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0235 | 0.3298 | 0.3303 |
Echinococcus granulosus | activin receptor type | 0.0277 | 0.4041 | 0.402 |
Trichomonas vaginalis | cyclins, putative | 0.0091 | 0.0708 | 0.2774 |
Trypanosoma cruzi | GMP reductase | 0.0246 | 0.3497 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0189 | 0.2458 | 0.6999 |
Entamoeba histolytica | cyclin, putative | 0.0189 | 0.2458 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0189 | 0.2458 | 0.6999 |
Trichomonas vaginalis | cyclin D, putative | 0.0129 | 0.1382 | 0.5559 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0609 | 1 | 1 |
Echinococcus multilocularis | cyclin B3 1 | 0.0129 | 0.1382 | 0.1351 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0246 | 0.3497 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0316 | 0.4747 | 0.4754 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0609 | 1 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0263 | 0.3793 | 0.3771 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0189 | 0.2458 | 0.2435 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0246 | 0.3497 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0246 | 0.3497 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0235 | 0.3298 | 0.3279 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0246 | 0.3497 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0129 | 0.1382 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.2458 | 0.2462 |
Schistosoma mansoni | cyclin B | 0.0189 | 0.2458 | 0.2431 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0276 | 0.402 | 0.3999 |
Toxoplasma gondii | hypothetical protein | 0.0098 | 0.0826 | 0.2282 |
Toxoplasma gondii | IMP dehydrogenas | 0.0246 | 0.3497 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0102 | 0.0913 | 0.0881 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0608 | 0.9985 | 1 |
Echinococcus multilocularis | activin receptor type | 0.0277 | 0.4041 | 0.402 |
Schistosoma mansoni | protein kinase | 0.0609 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0129 | 0.1382 | 0.1351 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0608 | 0.9985 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0129 | 0.1382 | 0.5559 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0129 | 0.1397 | 0.0954 |
Trichomonas vaginalis | cyclins, putative | 0.0189 | 0.2458 | 1 |
Echinococcus multilocularis | cyclins | 0.0129 | 0.1382 | 0.1351 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0246 | 0.3497 | 1 |
Onchocerca volvulus | 0.0189 | 0.2458 | 1 | |
Plasmodium falciparum | cyclin | 0.0129 | 0.1382 | 0.421 |
Trichomonas vaginalis | cyclin B3, putative | 0.0129 | 0.1382 | 0.5559 |
Trypanosoma cruzi | cyclin, putative | 0.0189 | 0.2458 | 0.6999 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0151 | 0.0151 |
Trichomonas vaginalis | cyclin B, putative | 0.0189 | 0.2458 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0246 | 0.3497 | 0.3502 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0189 | 0.2458 | 0.6999 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0232 | 0.3234 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0246 | 0.3497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.2458 | 0.2462 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0316 | 0.4747 | 0.4735 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0235 | 0.3298 | 0.3303 |
Echinococcus multilocularis | cyclins | 0.0129 | 0.1382 | 0.1351 |
Brugia malayi | GMP reductase | 0.0102 | 0.0913 | 0.0881 |
Echinococcus multilocularis | cyclin b3 | 0.0129 | 0.1382 | 0.1351 |
Trypanosoma brucei | GMP reductase | 0.0246 | 0.3497 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0054 | 0.0036 | 0.0036 |
Echinococcus multilocularis | cyclin B | 0.0189 | 0.2458 | 0.2431 |
Echinococcus granulosus | cyclins | 0.0129 | 0.1382 | 0.1351 |
Entamoeba histolytica | cyclin family protein | 0.0129 | 0.1382 | 0.5559 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.