Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholesteryl ester transfer protein, plasma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0033 | 0.0033 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0255 | 0.743 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.0033 | 0.5 | |
Schistosoma mansoni | amidase | 0.0329 | 1 | 1 |
Onchocerca volvulus | 0.0041 | 0.0033 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0033 | 0.5 | |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.004 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0329 | 1 | 1 |
Onchocerca volvulus | 0.0041 | 0.0033 | 0.5 | |
Mycobacterium ulcerans | amidase | 0.004 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.004 | 0 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.004 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.0033 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0033 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0033 | 0.5 | |
Mycobacterium ulcerans | amidase | 0.004 | 0 | 0.5 |
Mycobacterium ulcerans | amidase | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | amidase, putative | 0.004 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.004 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0255 | 0.743 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0041 | 0.0033 | 0.0033 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.004 | 0 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | amidase, putative | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.0033 | 0.5 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0041 | 0.0033 | 0.0033 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0329 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.004 | 0 | 0.5 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.004 | 0 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0329 | 1 | 1 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.004 | 0 | 0.5 |
Mycobacterium ulcerans | amidase | 0.004 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0329 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.004 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0329 | 1 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0041 | 0.0033 | 0.0033 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0041 | 0.0033 | 0.0033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibitory concentration against Cholesterol ester transfer protein (CETP) in CETP fluorescence assay | ChEMBL. | 15975789 |
IC50 (binding) | = 0.2 uM | Inhibitory concentration against Cholesterol ester transfer protein (CETP) in CETP fluorescence assay | ChEMBL. | 15975789 |
T1/2 (ADMET) | = 4.2 hr | Half life period of the compound against Cholesterol ester transfer protein (CETP) determined in rat plasma | ChEMBL. | 15975789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.