Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0111 | 0.0944 | 1 |
Brugia malayi | prostaglandin transporter | 0.042 | 0.5809 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.1654 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0111 | 0.0944 | 0.0944 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.1654 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0111 | 0.0944 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0111 | 0.0944 | 0.1625 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0686 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 0.5809 | 1 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0031 | 0.0054 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0053 | 0.0031 | 0.0189 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.1654 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0686 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0031 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.1654 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.042 | 0.5809 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0111 | 0.0944 | 0.0944 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.1654 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0111 | 0.0944 | 0.0944 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0156 | 0.1654 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0111 | 0.0944 | 0.1625 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0111 | 0.0944 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 13 % | Percent inhibition of the compound at 10 uM concentration against human recombinant Prostaglandin G/H synthase 1 cloned and expressed in baculovirus (Sf9) | ChEMBL. | 11392547 |
Inhibition (binding) | = 13 % | Percent inhibition of the compound at 10 uM concentration against human recombinant Prostaglandin G/H synthase 1 cloned and expressed in baculovirus (Sf9) | ChEMBL. | 11392547 |
Inhibition (binding) | = 21 % | Percent inhibition at 100 nM concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9) | ChEMBL. | 11392547 |
Inhibition (binding) | = 21 % | Percent inhibition at 100 nM concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9) | ChEMBL. | 11392547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.