Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0888 | 0.1757 | 0.7949 | |
Loa Loa (eye worm) | hypothetical protein | 0.3725 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3725 | 1 | 1 |
Echinococcus granulosus | laminin | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0284 | 0 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.1637 | 0.3933 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 0.0313 | 0.0313 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1044 | 0.221 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1044 | 0.221 | 0.221 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0391 | 0.0313 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0284 | 0 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0391 | 0.0313 | 0.0313 |
Onchocerca volvulus | 0.1044 | 0.221 | 1 | |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0391 | 0.0313 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1044 | 0.221 | 0.221 |
Echinococcus multilocularis | laminin | 0.0284 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0391 | 0.0313 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.3725 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1044 | 0.221 | 1 |
Brugia malayi | Trypsin family protein | 0.1044 | 0.221 | 0.221 |
Toxoplasma gondii | PAN domain-containing protein | 0.1637 | 0.3933 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 nM | Inhibition of type-3 17 beta-hydroxysteroid dehydrogenase expressed in HEK-293 cells at 37 degree C pH 7.4; Not determined | ChEMBL. | 16078844 |
Inhibition (binding) | = 3 % | Inhibition of type-3 17 beta-hydroxysteroid dehydrogenase expressed in HEK-293 cells at 0.3 uM 37 degree C pH 7.4 | ChEMBL. | 16078844 |
Inhibition (binding) | = 94 % | Inhibition of type-3 17 beta-hydroxysteroid dehydrogenase expressed in HEK-293 cells at 3 uM 37 degree C pH 7.4 | ChEMBL. | 16078844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.