Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | d-amino acid oxidase | 0.2014 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.2014 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.1846 | 0 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.2014 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log EC50 (binding) | = 5.2 M | Effective concentration against mouse melanocortin receptor-5 expressed in 293 HEK cells | ChEMBL. | 15974575 |
-Log EC50 (binding) | = 5.5 M | Effective concentration against human melanocortin receptor-4 expressed in 293 HEK cells | ChEMBL. | 15974575 |
-Log IC50 (binding) | = 5.3 M | Displacement of [125I]-NDP-MSH from human melanocortin receptor-4 expressed in 293 HEK cells | ChEMBL. | 15974575 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.