Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0192 | 0.7116 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0159 | 0.4989 | 0.4989 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0238 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.017 | 0.571 | 0.1439 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.017 | 0.571 | 0.571 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 14.6 ug ml-1 | In vitro minimal inhibitory concentration of the compound against Candida albicans with percentage of resistant strains %R = 16 (MIC > 64 ug/mL) at a range of 2-32 ug/mL | ChEMBL. | 16078834 |
MIC (functional) | = 14.6 ug ml-1 | In vitro minimal inhibitory concentration of the compound against Candida albicans with percentage of resistant strains %R = 16 (MIC > 64 ug/mL) at a range of 2-32 ug/mL | ChEMBL. | 16078834 |
MIC50 (functional) | = 8 ug ml-1 | In vitro concentration of the compound causing 50% inhibition of Candida albicans with percentage of resistant strains %R = 16 (MIC > 64 ug/mL) at a range of 2-32 ug/mL | ChEMBL. | 16078834 |
MIC50 (functional) | = 8 ug ml-1 | In vitro concentration of the compound causing 50% inhibition of Candida albicans with percentage of resistant strains %R = 16 (MIC > 64 ug/mL) at a range of 2-32 ug/mL | ChEMBL. | 16078834 |
MIC90 (functional) | = 32 ug ml-1 | In vitro concentration of the compound causing 90% inhibition of Candida albicans with percentage of resistant strains %R = 16 (MIC > 64 ug/mL) at a range of 2-32 ug/mL | ChEMBL. | 16078834 |
MIC90 (functional) | = 32 ug ml-1 | In vitro concentration of the compound causing 90% inhibition of Candida albicans with percentage of resistant strains %R = 16 (MIC > 64 ug/mL) at a range of 2-32 ug/mL | ChEMBL. | 16078834 |
Ratio (functional) | = 2.9 | Ratio of the in vitro minimal inhibitory to that of bifonazole against Candida albicans (MICcompd/MICbifonazole) | ChEMBL. | 16078834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.