Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0376 | 0.0198 | 0.0213 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.068 | 0.9293 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.068 | 0.9293 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0507 | 0.4122 | 0.4436 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0507 | 0.4122 | 0.4436 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0376 | 0.0198 | 0.0213 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Inhibition of 100 nM-NECA stimulation of cAMP levels in human adenosine A2b receptor expressing CHO cells | ChEMBL. | 16033279 |
IC50 (binding) | > 1000 nM | Inhibition of 100 nM-NECA stimulation of cAMP levels in human adenosine A2b receptor expressing CHO cells | ChEMBL. | 16033279 |
Inhibition (binding) | = 10 % | Percent inhibition [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Inhibition (binding) | = 10 % | Percent inhibition of [3H]-ZM-241,385 binding to human adenosine 2Aa receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Inhibition (binding) | = 10 % | Percent inhibition of human adenosine A2b receptor expressed in CHO cells | ChEMBL. | 16033279 |
Inhibition (binding) | = 10 % | Percent inhibition [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Inhibition (binding) | = 10 % | Percent inhibition of [3H]-ZM-241,385 binding to human adenosine 2Aa receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Inhibition (binding) | = 10 % | Percent inhibition of human adenosine A2b receptor expressed in CHO cells | ChEMBL. | 16033279 |
Ki (binding) | = 27 nM | Inhibition of [3H]-MRE3008-F20 binding to human adenosine A3 receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Ki (binding) | = 27 nM | Inhibition of [3H]-MRE3008-F20 binding to human adenosine A3 receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Ki (binding) | > 1000 nM | Inhibition of [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Ki (binding) | > 1000 nM | Inhibition of [3H]-ZM-241,385 binding to human adenosine A2a receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Ki (binding) | > 1000 nM | Inhibition of [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Ki (binding) | > 1000 nM | Inhibition of [3H]-ZM-241,385 binding to human adenosine A2a receptor expressed in CHO cells; (n=3 - 6) | ChEMBL. | 16033279 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.