Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA topoisomerase II | 0.0183 | 0.1608 | 0.3436 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0848 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0146 | 0.1139 | 0.2433 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0236 | 0.227 | 0.227 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0154 | 0.124 | 0.3668 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0405 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0129 | 0.0275 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0183 | 0.1608 | 0.1608 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0183 | 0.1608 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0427 | 0.4681 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0183 | 0.1608 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0146 | 0.1139 | 0.7082 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0183 | 0.1608 | 0.3436 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0183 | 0.1608 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0183 | 0.1608 | 0.3436 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0427 | 0.4681 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0146 | 0.1139 | 0.2433 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0408 | 0.4443 | 0.4443 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0146 | 0.1139 | 0.3369 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0324 | 0.3381 | 0.7224 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0427 | 0.4681 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0154 | 0.124 | 0.265 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0183 | 0.1608 | 0.1608 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0427 | 0.4681 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0146 | 0.1139 | 0.2433 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0183 | 0.1608 | 0.3436 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0427 | 0.4681 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0146 | 0.1139 | 0.3369 |
Echinococcus granulosus | cathepsin b | 0.0427 | 0.4681 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0154 | 0.124 | 0.3668 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0324 | 0.3381 | 0.7224 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0408 | 0.4443 | 0.4443 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0427 | 0.4681 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0324 | 0.3381 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0154 | 0.124 | 0.265 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0183 | 0.1608 | 0.1608 |
Brugia malayi | Probable DNA topoisomerase II | 0.0183 | 0.1608 | 0.3436 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0405 | 0.0865 |
Toxoplasma gondii | cathepsin B | 0.0146 | 0.1139 | 0.1139 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0183 | 0.1608 | 0.3436 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0427 | 0.4681 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0171 | 0.1447 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0848 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0848 | 1 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0848 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.4681 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0324 | 0.3381 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0848 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0408 | 0.4443 | 0.4208 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0848 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0183 | 0.1608 | 0.3436 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0129 | 0.0275 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0848 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0427 | 0.4681 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0404 | 0.4397 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0183 | 0.1608 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0267 | 0.267 | 0.236 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0154 | 0.124 | 0.3668 |
Echinococcus granulosus | cathepsin b | 0.0427 | 0.4681 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0183 | 0.1608 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | > 3 % | Allosteric enhancer activity against adenosine A1 receptor | ChEMBL. | 16078833 |
Activity (binding) | > 3 % | Allosteric enhancer activity against adenosine A1 receptor | ChEMBL. | 16078833 |
Alloste ic enhan er (AE) (binding) | = 0 % | In vitro allosteric enhancer (AE) activity for adenosine A2A receptor at 50 uM | ChEMBL. | 16078833 |
Alloste ic enhan er (AE) (binding) | = 0 % | In vitro allosteric enhancer (AE) activity for adenosine A2A receptor at 50 uM | ChEMBL. | 16078833 |
Alloste ic enhan er (AE) (binding) | = 4.2 % | In vitro allosteric enhancer (AE) activity for adenosine A3 receptor at 50 uM | ChEMBL. | 16078833 |
Alloste ic enhan er (AE) (binding) | = 4.2 % | In vitro allosteric enhancer (AE) activity for adenosine A3 receptor at 50 uM | ChEMBL. | 16078833 |
Alloste ic enhan er (AE) (binding) | = 61.2 % | In vitro allosteric enhancer (AE) activity for adenosine A1 receptor at 50 uM | ChEMBL. | 16078833 |
Alloste ic enhan er (AE) (binding) | = 61.2 % | In vitro allosteric enhancer (AE) activity for adenosine A1 receptor at 50 uM | ChEMBL. | 16078833 |
Alloste ic enhan er (AE) (binding) | = 65.3 % | In vitro allosteric enhancer (AE) activity for adenosine A1 receptor at 50 uM | ChEMBL. | 16078833 |
Alloste ic enhan er (AE) (binding) | = 65.3 % | In vitro allosteric enhancer (AE) activity for adenosine A1 receptor at 50 uM | ChEMBL. | 16078833 |
EC50 (functional) | > 13 uM | Antagonist activity against adenosine A1 receptor | ChEMBL. | 16078833 |
EC50 (functional) | > 13 uM | Antagonist activity against adenosine A1 receptor | ChEMBL. | 16078833 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.