Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 124 uM | Cytotoxic concentration required to reduce HEL cell growth | ChEMBL. | 15801851 |
CC50 (functional) | = 124 uM | Cytotoxic concentration required to reduce HEL cell growth | ChEMBL. | 15801851 |
EC50 (functional) | > 80 uM | Effective concentration required to inhibit human cytomegalo virus Davis induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection | ChEMBL. | 15801851 |
EC50 (functional) | > 80 uM | Effective concentration required to reduce varicella-zoster virus OKA(TK) plaque formation after 5 days in HEL fibroblast cell line | ChEMBL. | 15801851 |
EC50 (functional) | > 80 uM | Effective concentration required to reduce varicella-zoster virus 07/1(TK-) plaque formation after 5 days in HEL fibroblast cell line | ChEMBL. | 15801851 |
EC50 (functional) | > 80 uM | Effective concentration required to inhibit human cytomegalo virus Davis induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection | ChEMBL. | 15801851 |
EC50 (functional) | > 80 uM | Effective concentration required to reduce varicella-zoster virus OKA(TK) plaque formation after 5 days in HEL fibroblast cell line | ChEMBL. | 15801851 |
EC50 (functional) | > 80 uM | Effective concentration required to reduce varicella-zoster virus 07/1(TK-) plaque formation after 5 days in HEL fibroblast cell line | ChEMBL. | 15801851 |
EC50 (functional) | > 400 uM | Effective concentration required to inhibit human cytomegalo virus AD-169 induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection | ChEMBL. | 15801851 |
EC50 (functional) | > 400 uM | Effective concentration required to inhibit human cytomegalo virus AD-169 induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection | ChEMBL. | 15801851 |
MCC (functional) | >= 400 uM | Minimum cytotoxic concentration required to cause a microscopically visible alteration of HEL fibroblast cell morphology | ChEMBL. | 15801851 |
MCC (functional) | >= 400 uM | Minimum cytotoxic concentration required to cause a microscopically visible alteration of HEL fibroblast cell morphology | ChEMBL. | 15801851 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.