Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Muscle positioning protein 4 | 0.025 | 0.1292 | 0.1298 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0293 | 0.1882 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0441 | 0.3873 | 0.5716 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0441 | 0.3873 | 0.5716 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.4724 | 0.7265 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0209 | 0.0747 | 0.0623 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0504 | 0.4724 | 0.7102 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0635 | 0.6502 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0635 | 0.6502 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0635 | 0.6502 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0575 | 0.568 | 0.8661 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0515 | 0.0792 |
Onchocerca volvulus | 0.025 | 0.1292 | 0.1298 | |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0241 | 0.1175 | 0.1576 |
Onchocerca volvulus | 0.0293 | 0.1882 | 0.2284 | |
Trypanosoma cruzi | prolyl endopeptidase | 0.0441 | 0.3873 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0441 | 0.3873 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.1882 | 0.2472 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0192 | 0.0515 | 0.0792 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0441 | 0.3873 | 0.5609 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0635 | 0.6502 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0293 | 0.1882 | 0.2284 |
Toxoplasma gondii | PAN domain-containing protein | 0.0894 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0293 | 0.1882 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.1882 | 0.2895 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0293 | 0.1882 | 0.1328 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.3873 | 0.5957 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0241 | 0.1175 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.4724 | 0.7265 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0241 | 0.1175 | 0.1576 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0441 | 0.3873 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0635 | 0.6502 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0293 | 0.1882 | 0.3785 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0241 | 0.1175 | 0.1576 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0441 | 0.3873 | 0.5609 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0241 | 0.1175 | 0.1576 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0293 | 0.1882 | 0.1328 |
Brugia malayi | Trypsin family protein | 0.0504 | 0.4724 | 0.703 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0241 | 0.1175 | 0.132 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0293 | 0.1882 | 0.2895 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.1292 | 0.1987 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0441 | 0.3873 | 0.5065 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0293 | 0.1882 | 0.3785 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0241 | 0.1175 | 0.1102 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.0515 | 0.0244 |
Onchocerca volvulus | 0.0504 | 0.4724 | 0.703 | |
Brugia malayi | Protein kinase domain containing protein | 0.0293 | 0.1882 | 0.2284 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0204 | 0.067 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0352 | 0.2679 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0441 | 0.3873 | 0.5065 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0635 | 0.6502 | 1 |
Onchocerca volvulus | 0.0359 | 0.2761 | 0.3752 | |
Toxoplasma gondii | prolyl endopeptidase | 0.0441 | 0.3873 | 0.3058 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0204 | 0.067 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0293 | 0.1882 | 0.0802 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 10.6 uM | Antiproliferative activity against prostate cancer PPC-1 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | = 10.6 uM | Antiproliferative activity against prostate cancer PPC-1 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | = 11.2 uM | Antiproliferative activity against prostate cancer LNCaP Cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | = 11.2 uM | Antiproliferative activity against prostate cancer LNCaP Cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative effect against RH7777 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer DU-145 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer PC-3 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer TSU-Pr1 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer DU-145 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer PC-3 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer TSU-Pr1 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15801848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.