Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative nachr subunit | 0.0236 | 0.1142 | 0.5653 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Onchocerca volvulus | 0.0098 | 0.0093 | 0.0402 | |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.2826 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.036 | 0.2093 | 0.2082 |
Brugia malayi | Cation transporter family protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0361 | 0.2099 | 0.5909 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0361 | 0.2099 | 0.3812 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0165 | 0.0602 | 0.167 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0236 | 0.1142 | 0.2063 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.2099 | 0.5909 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0341 | 0.1946 | 0.7447 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.019 | 0.0791 | 0.1422 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0361 | 0.2099 | 0.8034 |
Echinococcus multilocularis | nAChR subunit | 0.0098 | 0.0093 | 0.0147 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0165 | 0.0602 | 0.2826 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0297 | 0.1608 | 0.7647 |
Brugia malayi | Sushi domain | 0.019 | 0.0791 | 0.0779 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0236 | 0.1142 | 0.5412 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.019 | 0.0791 | 0.5235 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.019 | 0.0791 | 0.2204 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0098 | 0.0093 | 0.0309 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.087 | 0.2426 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.1077 |
Echinococcus multilocularis | laminin | 0.0282 | 0.1499 | 0.2717 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0098 | 0.0093 | 0.008 |
Onchocerca volvulus | 0.0349 | 0.201 | 1 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0089 | 0.0025 | 0.0012 |
Leishmania major | C-8 sterol isomerase-like protein | 0.036 | 0.2093 | 1 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0165 | 0.0602 | 0.059 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0165 | 0.0602 | 0.1077 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Brugia malayi | Cation transporter family protein | 0.0165 | 0.0602 | 0.059 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Echinococcus granulosus | c4b binding protein beta chain | 0.019 | 0.0791 | 0.3731 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.019 | 0.0791 | 0.2997 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.036 | 0.2093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0098 | 0.0093 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0341 | 0.1946 | 0.1936 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0236 | 0.1142 | 0.4348 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.019 | 0.0791 | 0.5235 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.2063 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.3198 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0633 | 0.1755 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.0073 | 1 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Onchocerca volvulus | Putative cubilin | 0.0089 | 0.0025 | 0.0058 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.1499 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.1499 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.2093 | 0.5892 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0165 | 0.0602 | 0.059 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0236 | 0.1142 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.201 | 0.5657 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.1665 | 0.4679 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0165 | 0.0602 | 0.167 |
Echinococcus multilocularis | serotonin receptor | 0.0297 | 0.1608 | 0.2915 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0165 | 0.0602 | 0.1077 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.036 | 0.2093 | 1 |
Echinococcus granulosus | C type lectin domian containing protein | 0.019 | 0.0791 | 0.3731 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.5412 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0165 | 0.0602 | 0.2826 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.1499 | 0.1488 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | 0.0098 | 0.0093 | 0.0402 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Brugia malayi | Fibulin-1 precursor | 0.0282 | 0.1499 | 0.1488 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | 0.0267 | 0.1379 | 0.6842 | |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1608 | 0.4519 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | nAChR subunit | 0.0165 | 0.0602 | 0.2826 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0165 | 0.0602 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1946 | 0.5477 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0428 | 0.2609 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0165 | 0.0602 | 0.1077 |
Echinococcus granulosus | Tolloid protein 1 | 0.0361 | 0.2099 | 1 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Echinococcus granulosus | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.2826 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0805 | 0.5484 | 1 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.3543 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0297 | 0.1608 | 0.2915 |
Brugia malayi | Trypsin family protein | 0.0349 | 0.201 | 0.1999 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0165 | 0.0602 | 0.227 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0165 | 0.0602 | 0.059 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0165 | 0.0602 | 0.2826 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0297 | 0.1608 | 0.6144 |
Loa Loa (eye worm) | ACC-1 protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.0073 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0282 | 0.1499 | 0.5726 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0165 | 0.0602 | 0.2826 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0098 | 0.0093 | 0.008 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | LGC-31 protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1946 | 0.5477 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0165 | 0.0602 | 0.059 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0236 | 0.1142 | 0.4348 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Entamoeba histolytica | hypothetical protein | 0.0098 | 0.0093 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0236 | 0.1142 | 0.113 |
Echinococcus granulosus | nAChR subunit | 0.0098 | 0.0093 | 0.0385 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0098 | 0.0093 | 0.008 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0282 | 0.1499 | 0.1488 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Echinococcus multilocularis | fibrillin 1 | 0.0282 | 0.1499 | 0.2717 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0098 | 0.0093 | 0.0309 |
Plasmodium falciparum | apical sushi protein | 0.019 | 0.0791 | 1 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.075 | 0.2089 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0025 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Brugia malayi | GCC2 and GCC3 family protein | 0.02 | 0.087 | 0.0858 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.019 | 0.0791 | 0.0779 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.1499 | 0.4211 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Plasmodium vivax | apical sushi protein, putative | 0.019 | 0.0791 | 1 |
Echinococcus granulosus | laminin | 0.0282 | 0.1499 | 0.7127 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Loa Loa (eye worm) | ACC-1 protein | 0.0165 | 0.0602 | 0.167 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1608 | 0.4519 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Onchocerca volvulus | Arrow homolog | 0.0282 | 0.1499 | 0.7444 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | Cation transporter family protein | 0.0236 | 0.1142 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0165 | 0.0602 | 0.059 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0165 | 0.0602 | 0.059 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0161 | 0.0577 | 0.2172 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0349 | 0.201 | 0.7691 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Echinococcus multilocularis | C type lectin domian containing protein | 0.019 | 0.0791 | 0.1422 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0282 | 0.1499 | 0.4211 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0098 | 0.0093 | 0.0309 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0098 | 0.0093 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.201 | 0.5657 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0236 | 0.1142 | 0.5412 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 63.23 uM | In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) | ChEMBL. | 15857119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.