Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.2546 | 0.2587 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.2546 | 0.2587 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.2546 | 0.2587 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0182 | 0 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.2546 | 0.2587 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.2546 | 0.2587 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0182 | 0 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.2546 | 0.2587 | 0.5 |
Echinococcus granulosus | protection of telomeres protein 1 | 0.0623 | 0.0483 | 0.5 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0623 | 0.0483 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0182 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0182 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0182 | 0 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.6775 | 0.7214 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0182 | 0 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.2546 | 0.2587 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.2546 | 0.2587 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 ug ml-1 | Inhibitory concentration against cytotoxicity in VERO cell line; n.d.=not determined | ChEMBL. | 15801862 |
Inhibition (functional) | = 90 % | Tested for the inhibition of Mycobacterium tuberculosis growth at a dose of 6.25 ug/mL | ChEMBL. | 15801862 |
Inhibition (functional) | = 90 % | Tested for the inhibition of Mycobacterium tuberculosis growth at a dose of 6.25 ug/mL | ChEMBL. | 15801862 |
MIC (functional) | = 6.25 ug ml-1 | Minimum inhibitory concentration of the compound against Mycobacterium tuberculosis H37Rv | ChEMBL. | 15801862 |
MIC (functional) | = 6.25 ug ml-1 | Minimum inhibitory concentration of the compound against Mycobacterium tuberculosis H37Rv | ChEMBL. | 15801862 |
Selectivity index (functional) | 0 | Selectivity index (IC50:MIC) of the compound; n.d.=not determined | ChEMBL. | 15801862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.