Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.101 | 0.2189 | 1 |
Loa Loa (eye worm) | subtilase | 0.2697 | 1 | 0.5 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.2697 | 1 | 0.5 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.101 | 0.2189 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 13.1 uM | Concentration giving 50% relaxation of the 30 mM KCl-induced contraction of rat aortic rings (n=6) | ChEMBL. | 15887958 |
IC50 (functional) | = 1.7 uM | Concentration required for 50% inhibition of insulin release in rat pancreatic B-cells | ChEMBL. | 15887958 |
pKa | = 8.96 | Ionization constant of the compound was determined | ChEMBL. | 15887958 |
Ratio (functional) | = 7.7 | ED50/IC50 ratio was determined | ChEMBL. | 15887958 |
Residual insulin release (functional) | = 7.1 % | Effect of the compound on insulin secretion from rat pancreatic islets at 50 uM concentration (n=13) | ChEMBL. | 15887958 |
Residual insulin release (functional) | = 7.4 % | Effect of the compound on insulin secretion from rat pancreatic islets at 10 uM concentration (n=13) | ChEMBL. | 15887958 |
Residual insulin release (functional) | = 71.5 % | Effect of the compound on insulin secretion from rat pancreatic islets at 1 uM concentration (n=14) | ChEMBL. | 15887958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.