TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.239 | Formula: C14H19Cl2N5O2
H donors: 2 H acceptors: 0 LogP: 2.13 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: NC1=NC(N(C(=N1)N)OCCCOc1ccc(c(c1)Cl)Cl)(C)C
InChi: 1S/C14H19Cl2N5O2/c1-14(2)20-12(17)19-13(18)21(14)23-7-3-6-22-9-4-5-10(15)11(16)8-9/h4-5,8H,3,6-7H2,1-2H3,(H4,17,18,19,20)
InChiKey: SVYAEPYBDPIXIA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin b	0.0218006	0.510879	0.60073
Giardia lamblia	Cathepsin B precursor	0.0101621	0.0968153	0.5
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	TYRA-2 protein	0.015496	0.286579	0.286579
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.015496	0.286579	0.560952
Onchocerca volvulus		0.015496	0.286579	1
Echinococcus multilocularis	neuropeptide Y receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Echinococcus granulosus	biogenic amine 5HT receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Onchocerca volvulus		0.015496	0.286579	1
Echinococcus granulosus	neuropeptides capa receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	amine GPCR	0.015496	0.286579	0.560952
Schistosoma mansoni	amine GPCR	0.015496	0.286579	0.560952
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.015496	0.286579	0.336981
Echinococcus granulosus	peptide allatostatin:somatostatin	0.015496	0.286579	0.336981
Brugia malayi	cathepsin B-like cysteine proteinase	0.0218006	0.510879	0.510879
Schistosoma mansoni	opsin-like receptor	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	neuropeptide receptor	0.015496	0.286579	0.336981
Echinococcus granulosus	neuropeptide s receptor	0.015496	0.286579	0.336981
Echinococcus granulosus	allatostatin A receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	orexin receptor type 2	0.015496	0.286579	0.336981
Brugia malayi	putative neuropeptide receptor NPR1	0.015496	0.286579	0.286579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	melatonin receptor type 1A	0.015496	0.286579	0.286579
Onchocerca volvulus		0.015496	0.286579	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.00744083	0	0.5
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	opsin-like receptor	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Echinococcus granulosus	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Schistosoma mansoni	hypothetical protein	0.015496	0.286579	0.560952
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.015496	0.286579	0.336981
Echinococcus granulosus	cathepsin b	0.0218006	0.510879	0.60073
Echinococcus granulosus	serotonin receptor	0.015496	0.286579	0.336981
Onchocerca volvulus		0.015496	0.286579	1
Schistosoma mansoni	neuropeptide receptor	0.015496	0.286579	0.560952
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.015496	0.286579	0.286579
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0218006	0.510879	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.015496	0.286579	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.015496	0.286579	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Loa Loa (eye worm)	neuropeptide F receptor	0.015496	0.286579	0.286579
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.015496	0.286579	0.286579
Echinococcus granulosus	neuropeptide receptor	0.015496	0.286579	0.336981
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	neuropeptide Y receptor	0.015496	0.286579	0.336981
Echinococcus multilocularis	g protein coupled receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	neuropeptide receptor A26	0.015496	0.286579	0.336981
Schistosoma mansoni	amine GPCR	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Plasmodium vivax	vivapain-2	0.00744083	0	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.015496	0.286579	0.560952
Echinococcus multilocularis	G protein coupled receptor 139	0.015496	0.286579	0.336981
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0218006	0.510879	1
Onchocerca volvulus		0.015496	0.286579	1
Brugia malayi	follicle stimulating hormone receptor	0.015496	0.286579	0.286579
Echinococcus multilocularis	cathepsin b	0.0218006	0.510879	0.60073
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.015496	0.286579	0.336981
Schistosoma mansoni	biogenic amine (5HT) receptor	0.015496	0.286579	0.560952
Brugia malayi	G-protein coupled receptor	0.015496	0.286579	0.286579
Schistosoma mansoni	biogenic amine receptor	0.015496	0.286579	0.560952
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.015496	0.286579	0.336981
Echinococcus granulosus	dro:myosuppressin receptor	0.015496	0.286579	0.336981
Echinococcus multilocularis	neuropeptides capa receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	opsin-like receptor	0.015496	0.286579	0.560952
Echinococcus granulosus	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	somatostatin receptor	0.015496	0.286579	0.336981
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.015496	0.286579	0.336981
Schistosoma mansoni	hypothetical protein	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.0218006	0.510879	0.510879
Echinococcus granulosus	neuropeptide FF receptor 2	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	neuropeptide s receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.015496	0.286579	0.560952
Onchocerca volvulus		0.015496	0.286579	1
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	alpha 1A adrenergic receptor	0.015496	0.286579	0.336981
Echinococcus multilocularis	cathepsin b	0.0218006	0.510879	0.60073
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	g protein coupled receptor	0.015496	0.286579	0.336981
Brugia malayi	putative neuropeptide receptor	0.015496	0.286579	0.286579
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.015496	0.286579	0.560952
Brugia malayi	Dopamine receptor	0.015496	0.286579	0.286579
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Toxoplasma gondii	cathepsin B	0.0101621	0.0968153	1
Echinococcus granulosus	neuropeptide receptor	0.015496	0.286579	0.336981
Echinococcus granulosus	tm gpcr rhodopsin	0.015496	0.286579	0.336981
Onchocerca volvulus		0.015496	0.286579	1
Schistosoma mansoni	neuropeptide F-like receptor	0.015496	0.286579	0.560952
Schistosoma mansoni	biogenic amine receptor	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Onchocerca volvulus		0.015496	0.286579	1
Echinococcus granulosus	g protein coupled receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	cathepsin B	0.0101621	0.0968153	0.0968153
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Onchocerca volvulus		0.015496	0.286579	1
Echinococcus granulosus	hypothetical protein	0.015496	0.286579	0.336981
Brugia malayi	Tachykinin-like peptides receptor 99D	0.015496	0.286579	0.286579
Echinococcus multilocularis	neuropeptides capa receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.015496	0.286579	0.336981
Brugia malayi	ORL1-like opioid receptor	0.015496	0.286579	0.286579
Echinococcus granulosus	G protein coupled receptor 139	0.015496	0.286579	0.336981
Schistosoma mansoni	neuropeptide receptor	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0101621	0.0968153	0.189507
Echinococcus granulosus	fmrfamide receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Brugia malayi	RE15519p	0.015496	0.286579	0.286579
Giardia lamblia	Cathepsin B precursor	0.0101621	0.0968153	0.5
Echinococcus multilocularis	fmrfamide receptor	0.015496	0.286579	0.336981
Echinococcus multilocularis	allatostatin A receptor	0.015496	0.286579	0.336981
Echinococcus granulosus	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Onchocerca volvulus		0.015496	0.286579	1
Schistosoma mansoni	adenoreceptor	0.015496	0.286579	0.560952
Echinococcus granulosus	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Onchocerca volvulus		0.015496	0.286579	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.015496	0.286579	0.336981
Echinococcus multilocularis	neuropeptide FF receptor 2	0.015496	0.286579	0.336981
Echinococcus granulosus	neuropeptide Y receptor	0.015496	0.286579	0.336981
Brugia malayi	larval opioid receptor	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	dro:myosuppressin receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.015496	0.286579	0.560952
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.015496	0.286579	0.560952
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.015496	0.286579	0.286579
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.015496	0.286579	0.336981
Echinococcus granulosus	sex peptide receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.015496	0.286579	0.560952
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.00744083	0	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.015496	0.286579	0.560952
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.015496	0.286579	0.560952
Plasmodium vivax	vivapain-2	0.00744083	0	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.015496	0.286579	0.560952
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	biogenic amine (5HT) receptor	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.0355488	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Echinococcus multilocularis	orexin receptor type 2	0.015496	0.286579	0.336981
Brugia malayi	sulfakinin receptor protein	0.0355488	1	1
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	somatostatin receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.015496	0.286579	0.286579
Echinococcus multilocularis	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0218006	0.510879	1
Schistosoma mansoni	amine GPCR	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	neuropeptide Y receptor	0.015496	0.286579	0.336981
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0101621	0.0968153	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.015496	0.286579	0.560952
Echinococcus granulosus	g protein coupled receptor	0.015496	0.286579	0.336981
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	G-protein coupled receptor	0.015496	0.286579	0.286579
Brugia malayi	Melatonin receptor type 1A	0.015496	0.286579	0.286579
Echinococcus multilocularis	neuropeptide receptor	0.015496	0.286579	0.336981
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.015496	0.286579	0.336981
Echinococcus granulosus	tm gpcr rhodopsin	0.015496	0.286579	0.336981
Echinococcus multilocularis	G-protein coupled receptor, putative	0.015496	0.286579	0.336981
Echinococcus multilocularis	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0218006	0.510879	1
Schistosoma mansoni	neuropeptide receptor	0.015496	0.286579	0.560952
Echinococcus multilocularis	serotonin receptor	0.015496	0.286579	0.336981
Entamoeba histolytica	cysteine proteinase, putative	0.00744083	0	0.5
Schistosoma mansoni	myosin xvIII	0.015496	0.286579	0.560952
Schistosoma mansoni	neuropeptide F-like receptor	0.015496	0.286579	0.560952
Brugia malayi	G protein-coupled receptor	0.015496	0.286579	0.286579
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.015496	0.286579	0.286579
Schistosoma mansoni	hypothetical protein	0.015496	0.286579	0.560952
Brugia malayi	neuropeptide F receptor	0.015496	0.286579	0.286579
Schistosoma mansoni	histamine h1 receptor	0.015496	0.286579	0.560952
Echinococcus granulosus	7tm_1 domain containing protein	0.015496	0.286579	0.336981
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	g protein coupled receptor	0.015496	0.286579	0.336981
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Brugia malayi	GnHR receptor homolog	0.015496	0.286579	0.286579
Onchocerca volvulus		0.015496	0.286579	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.00744083	0	0.5
Brugia malayi	Dopamine receptor protein 1	0.015496	0.286579	0.286579
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.015496	0.286579	0.286579
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0101621	0.0968153	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0313447	0.85043	1
Onchocerca volvulus		0.015496	0.286579	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	G-protein coupled receptor	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	g-protein coupled receptor	0.015496	0.286579	0.336981
Echinococcus multilocularis	g-protein coupled receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	alpha-1 adrenergic receptor	0.015496	0.286579	0.560952
Echinococcus granulosus	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Echinococcus granulosus	neuropeptide receptor A26	0.015496	0.286579	0.336981
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.015496	0.286579	0.336981
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Brugia malayi	G protein-coupled receptor F59B2.13	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.015496	0.286579	0.286579
Brugia malayi	AKH receptor	0.015496	0.286579	0.286579
Schistosoma mansoni	hypothetical protein	0.015496	0.286579	0.560952
Schistosoma mansoni	amine GPCR	0.015496	0.286579	0.560952
Brugia malayi	Serotonin receptor	0.015496	0.286579	0.286579
Onchocerca volvulus		0.015496	0.286579	1
Brugia malayi	Dopamine receptor protein 2	0.015496	0.286579	0.286579
Echinococcus multilocularis	g protein coupled receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	neuropeptide F receptor	0.015496	0.286579	0.286579
Brugia malayi	neuropeptide F receptor	0.015496	0.286579	0.286579
Entamoeba histolytica	cysteine proteinase, putative	0.00744083	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.015496	0.286579	0.336981
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.015496	0.286579	0.560952
Echinococcus multilocularis	sex peptide receptor	0.015496	0.286579	0.336981
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.015496	0.286579	0.560952
Echinococcus multilocularis	serotonin receptor	0.015496	0.286579	0.336981
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0101621	0.0968153	1
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Schistosoma mansoni	neuropeptide receptor	0.015496	0.286579	0.560952
Brugia malayi	Serotonin receptor	0.015496	0.286579	0.286579
Schistosoma mansoni	biogenic amine receptor	0.015496	0.286579	0.560952
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.015496	0.286579	0.286579
Onchocerca volvulus		0.015496	0.286579	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101621	0.0968153	0.189507
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.015496	0.286579	0.336981
Echinococcus multilocularis	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.015496	0.286579	0.560952
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0313447	0.85043	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.015496	0.286579	0.560952
Brugia malayi	hypothetical protein	0.0355488	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Onchocerca volvulus		0.015496	0.286579	1
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Loa Loa (eye worm)	hypothetical protein	0.015496	0.286579	0.286579
Onchocerca volvulus		0.015496	0.286579	1
Giardia lamblia	Cathepsin B precursor	0.0101621	0.0968153	0.5
Echinococcus multilocularis	fmrfamide receptor	0.015496	0.286579	0.336981
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	tm gpcr rhodopsin	0.015496	0.286579	0.336981
Echinococcus multilocularis	rhodopsin orphan GPCR	0.015496	0.286579	0.336981
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0218006	0.510879	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.015496	0.286579	0.286579
Brugia malayi	hypothetical protein	0.015496	0.286579	0.286579
Echinococcus granulosus	neuropeptides capa receptor	0.015496	0.286579	0.336981
Brugia malayi	G-protein coupled receptor	0.015496	0.286579	0.286579
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.015496	0.286579	0.286579
Entamoeba histolytica	cysteine protease, putative	0.00744083	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.009 ng ml-1	In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-sensitive strain (D6)	ChEMBL.	15828818
IC50 (functional)	= 0.009 ng ml-1	In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-sensitive strain (D6)	ChEMBL.	15828818
IC50 (functional)	= 0.028 ng ml-1	In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-resistant strain (W2)	ChEMBL.	15828818
IC50 (functional)	= 0.028 ng ml-1	In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-resistant strain (W2)	ChEMBL.	15828818

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum		15828818

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL192579

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 336070