Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | e3 ubiquitin protein ligase siah1 | 0.1518 | 0.5 | 0.5 |
Schistosoma mansoni | ubiquitin ligase sina (ec 6.3.2.-) (seven in absentia homolog)(smsina) | 0.1518 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1518 | 0.5 | 0.5 |
Echinococcus granulosus | e3 ubiquitin protein ligase siah1 | 0.1518 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 625 ug ml-1 | Inhibitory concentration against cytotoxicity in VERO cell line | ChEMBL. | 15801862 |
Inhibition (functional) | = 98 % | Tested for the inhibition of Mycobacterium tuberculosis growth at a dose of 6.25 ug/mL | ChEMBL. | 15801862 |
Inhibition (functional) | = 98 % | Tested for the inhibition of Mycobacterium tuberculosis growth at a dose of 6.25 ug/mL | ChEMBL. | 15801862 |
MIC (functional) | = 6.25 ug ml-1 | Minimum inhibitory concentration of the compound against Mycobacterium tuberculosis H37Rv | ChEMBL. | 15801862 |
MIC (functional) | = 6.25 ug ml-1 | Minimum inhibitory concentration of the compound against Mycobacterium tuberculosis H37Rv | ChEMBL. | 15801862 |
Selectivity index (functional) | > 10 | Selectivity index (IC50:MIC) of the compound | ChEMBL. | 15801862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.