Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.12986 | 1 | 1 |
Loa Loa (eye worm) | STAT protein | 0.0280962 | 0.159516 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0198113 | 0.0910888 | 0.571034 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0106177 | 0.0151569 | 0.13412 |
Brugia malayi | Telomerase reverse transcriptase | 0.0894475 | 0.666228 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0198113 | 0.0910888 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0198113 | 0.0910888 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0404121 | 0.261235 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0198113 | 0.0910888 | 0.5 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0280962 | 0.159516 | 0.239431 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0198113 | 0.0910888 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0194002 | 0.0876934 | 0.961281 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0198113 | 0.0910888 | 1 |
Schistosoma mansoni | amine GPCR | 0.0225472 | 0.113685 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0404121 | 0.261235 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0404121 | 0.261235 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0198113 | 0.0910888 | 0.136723 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0404121 | 0.261235 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0198113 | 0.0910888 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0404121 | 0.261235 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0404121 | 0.261235 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0404121 | 0.261235 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0404121 | 0.261235 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 20.9 ug ml-1 | Antiamoebic activity against Entamoeba histolytica | ChEMBL. | No reference |
IC50 (functional) | = 3.39 uM | In vitro antiplasmodial activity of the compound against chloroquine-resistant strain FcB1 of Plasmodium falciparum | ChEMBL. | 15863333 |
IC50 (functional) | = 3.39 uM | In vitro antiplasmodial activity of the compound against chloroquine-resistant strain FcB1 of Plasmodium falciparum | ChEMBL. | 15863333 |
IC50 (functional) | = 36.55 uM | Cytotoxicity of the compound against rat L-6 cell line | ChEMBL. | 15863333 |
Selectivity index (functional) | = 10.8 uM | Selectivity Index is expressed as the ratio of cytotoxicity (IC50) against rat L-6 cell line to that of antiplasmodial activity (IC50) of chloroquine-resistant strain FcB1 of Plasmodium falciparum | ChEMBL. | 15863333 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 15863333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.