Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.024 | 0.546 | 0.546 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0286 | 0.7388 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0256 | 0.6114 | 0.1439 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0349 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0256 | 0.6114 | 0.6114 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 23.1 uM | Concentration required for relaxation of the 30 mM KCl-induced contraction of rat aortic rings (n=4) | ChEMBL. | 15887958 |
pKa | = 7.91 | Ionization constant of the compound was determined | ChEMBL. | 15887958 |
Residual insulin release (functional) | 0 % | Effect of the compound on insulin secretion from rat pancreatic islets at 1 uM concentration; N.D.=not determined | ChEMBL. | 15887958 |
Residual insulin release (functional) | = 4.8 % | Effect of the compound on insulin secretion from rat pancreatic islets at 50 uM concentration (n=14) | ChEMBL. | 15887958 |
Residual insulin release (functional) | = 64 % | Effect of the compound on insulin secretion from rat pancreatic islets at 10 uM concentration (n=37) | ChEMBL. | 15887958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.