Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0488 | 0.4975 | 0.4975 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0707 | 0.8807 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0642 | 0.7673 | 0.7673 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.3071 | 0.1369 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.3071 | 0.1369 |
Echinococcus multilocularis | NMDA receptor | 0.0225 | 0.0373 | 0.0373 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0379 | 0.3071 | 0.3071 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0488 | 0.4975 | 0.4975 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0395 | 0.3354 | 0.7358 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0488 | 0.4975 | 0.4975 |
Echinococcus granulosus | glutamate receptor 2 | 0.0642 | 0.7673 | 0.7673 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0707 | 0.8807 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0225 | 0.0373 | 0.0373 |
Echinococcus granulosus | glutamate receptor 4 | 0.0379 | 0.3071 | 0.3071 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0775 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.3071 | 0.1369 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0327 | 0.2161 | 0.2161 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0512 | 0.5398 | 0.5398 |
Schistosoma mansoni | glutamate receptor kainate | 0.042 | 0.3782 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0488 | 0.4975 | 0.4975 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0775 | 1 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0707 | 0.8807 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0327 | 0.2161 | 0.2161 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0297 | 0.1621 | 0.1621 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0488 | 0.4975 | 0.4975 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0225 | 0.0373 | 0.0373 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0512 | 0.5398 | 0.5398 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0488 | 0.4975 | 0.4975 |
Schistosoma mansoni | glutamate receptor kainate | 0.042 | 0.3782 | 1 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0225 | 0.0373 | 0.0373 |
Echinococcus granulosus | glutamate receptor 1 | 0.0379 | 0.3071 | 0.3071 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0775 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0707 | 0.8807 | 0.8807 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 100 % | Regulation of IGFBP-4 transcription in SAOS-2 cells expressing human estrogen receptor beta at 1 uM relative to 10 uM 17-beta-estradiol | ChEMBL. | 15943471 |
Activity (functional) | = 100 % | Regulation of IGFBP-4 transcription in SAOS-2 cells expressing human estrogen receptor beta at 1 uM relative to 10 uM 17-beta-estradiol | ChEMBL. | 15943471 |
IC50 (binding) | = 2.5 nM | Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor beta expressed in Escherichia coli | ChEMBL. | 15943471 |
IC50 (binding) | = 2.5 nM | Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor beta expressed in Escherichia coli | ChEMBL. | 15943471 |
IC50 (binding) | = 125 nM | Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha expressed in Escherichia coli | ChEMBL. | 15943471 |
IC50 (binding) | = 125 nM | Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha expressed in Escherichia coli | ChEMBL. | 15943471 |
Ratio (binding) | = 50 | Relative inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha and beta expressed in Escherichia coli | ChEMBL. | 15943471 |
Ratio (binding) | = 50 | Relative inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha and beta expressed in Escherichia coli | ChEMBL. | 15943471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.