Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | neuropeptide receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | larval opioid receptor | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | putative neuropeptide receptor | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | AKH receptor | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | sulfakinin receptor protein | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0101 | 0.011 | 0.0135 |
Loa Loa (eye worm) | glutamate receptor | 0.0203 | 0.6449 | 0.6574 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.011 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.9752 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | ORL1-like opioid receptor | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | amine GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | G-protein coupled receptor | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | neuropeptide receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | G-protein coupled receptor | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.011 | 0.0135 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.017 | 0.4407 | 0.4647 |
Schistosoma mansoni | biogenic amine receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | amine GPCR | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | neuropeptide F receptor | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | Dopamine receptor protein 2 | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | G protein-coupled receptor | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | Serotonin receptor | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | adenoreceptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | amine GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | myosin xvIII | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | neuropeptide receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | Melatonin receptor type 1A | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0101 | 0.011 | 0.0135 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.017 | 0.4407 | 0.4647 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0101 | 0.011 | 0.0135 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.025 | 0.9356 | 1 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0184 | 0.5266 | 0.8166 |
Brugia malayi | neuropeptide F receptor | 0.0101 | 0.011 | 0.0171 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.025 | 0.9356 | 1 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | opsin-like receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0101 | 0.011 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.9356 | 0.9589 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | amine GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | amine GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0231 | 0.8173 | 1 |
Brugia malayi | GnHR receptor homolog | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | Serotonin receptor | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | RE15519p | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | histamine h1 receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | biogenic amine receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.017 | 0.4407 | 0.5392 |
Schistosoma mansoni | biogenic amine receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | opsin-like receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | Dopamine receptor protein 1 | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | Dopamine receptor | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | opsin-like receptor | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | follicle stimulating hormone receptor | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0101 | 0.011 | 0.0171 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0101 | 0.011 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0203 | 0.6449 | 1 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0101 | 0.011 | 0.0135 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0101 | 0.011 | 0.0171 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 2 % | Percent displacement of [3H]-CGS-21,680 binding to adenosine A2A receptors of bovine striatal membranes at 0.00005 M | ChEMBL. | 15743197 |
Displacement (binding) | = 30 % | Percent displacement of [125I]-AB-MECA binding to adenosine A3 receptors of bovine cortical membranes at 0.00005 M | ChEMBL. | 15743197 |
IC50 (binding) | = 304 nM | Inhibition of adenylyl cyclase activity in rat cortical membranes | ChEMBL. | 15743197 |
Inhibition (binding) | = 18.1 % | Maximum percent inhibition of adenylyl cyclase activity in rat cortical membranes | ChEMBL. | 15743197 |
Ki (binding) | = 350 nM | Displacement of [3H]-DPCPX binding to adenosine A1 receptors of bovine cortical membranes | ChEMBL. | 15743197 |
Ratio (binding) | > 28.6 | Relative affinities against adenosine A2A and A1 receptors (ratio of KiA2A/KiA1) | ChEMBL. | 15743197 |
Ratio (binding) | > 28.6 | Relative affinities for adenosine A3 and A1 receptors (ratio of KiA3/KiA1) | ChEMBL. | 15743197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.