Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0162 | 0.9911 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0041 | 0.1223 | 0.5 |
Brugia malayi | glutathione reductase | 0.0162 | 0.9911 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0162 | 0.9911 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0041 | 0.1223 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0041 | 0.1223 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0162 | 0.9911 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0162 | 0.9911 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0041 | 0.1223 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0162 | 0.9911 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0162 | 0.9911 | 1 |
Leishmania major | trypanothione reductase | 0.0162 | 0.9911 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0162 | 0.9911 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0041 | 0.1223 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0164 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0041 | 0.1223 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0162 | 0.9911 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0041 | 0.1223 | 0.1234 |
Brugia malayi | Thioredoxin reductase | 0.0162 | 0.9911 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0041 | 0.1223 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0162 | 0.9911 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0041 | 0.1223 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0041 | 0.1223 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0041 | 0.1223 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0041 | 0.1223 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0162 | 0.9911 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibitory concentration against MurA enzyme in Escherichia coli | ChEMBL. | 15863310 |
IC50 (binding) | = 50 uM | Inhibitory concentration against MurB enzyme in Escherichia coli | ChEMBL. | 15863310 |
IC50 (binding) | > 50 uM | Inhibitory concentration against MurA enzyme in Escherichia coli | ChEMBL. | 15863310 |
IC50 (binding) | = 50 uM | Inhibitory concentration against MurB enzyme in Escherichia coli | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of methicillin resistant Staphylococcus aureus GC 1131 | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of methicillin susceptible Staphylococcus aureus GC 4543 | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of vancomycin susceptible (ATCC) Enterococcus faecalis GC 4555 | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of vancomycin resistant Enterococcus faecalis GC 2242 (VRE) | ChEMBL. | 15863310 |
MIC (functional) | = 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of penicillin resistant Streptococcus pneumoniae GC 1894 (PRSP) | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of penicillin resistant Streptococcus pneumoniae GC 1894 (PRSP) in the presence of 4% bovine serum albumin | ChEMBL. | 15863310 |
MIC (functional) | = 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of methicillin-susceptible Coagulase negative staphylococcus GC 646 (MSCNS) | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4559 | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4560 | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4559 | ChEMBL. | 15863310 |
MIC (functional) | > 200 uM | Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4560 | ChEMBL. | 15863310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.