Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1721 | 0.2644 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.1721 | 0.2644 | 0.5 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0059 | 0.0069 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1721 | 0.2644 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1721 | 0.2644 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1721 | 0.2644 | 0.5 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0059 | 0.0069 |
Echinococcus granulosus | protection of telomeres protein 1 | 0.0564 | 0.0785 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1721 | 0.2644 | 0.5 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0564 | 0.0785 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0009 | 0.1524 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0009 | 0.1524 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0059 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0059 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.4581 | 0.7236 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1721 | 0.2644 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1721 | 0.2644 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 100 uM | Cytotoxic concentration required to reduce the viability of mock infected MT-4 cells determined by MTT method | ChEMBL. | 15916438 |
CC50 (functional) | > 100 uM | Cytotoxic concentration required to reduce the viability of mock infected MT-4 cells determined by MTT method | ChEMBL. | 15916438 |
EC50 (functional) | = 65 uM | Effective concentration require to protect MT-4 cells from human immunodeficiency virus type 1 induced cytopathogenicity was determined by MTT method | ChEMBL. | 15916438 |
EC50 (functional) | = 65 uM | Effective concentration require to protect MT-4 cells from human immunodeficiency virus type 1 induced cytopathogenicity was determined by MTT method | ChEMBL. | 15916438 |
SI (functional) | > 1.5 | Ratio of CC50 to that of EC50 determined in MT-4 cells | ChEMBL. | 15916438 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.