Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | prolyl endopeptidase | 0.0135 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0135 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0135 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0135 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0135 | 1 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0121 | 0.8259 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0054 | 0 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0135 | 1 | 0.5 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0135 | 1 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activation (functional) | = 4 % | Percentage activation of MCF-7-2a cells at 1 uM | ChEMBL. | 15658860 |
Activation (functional) | = 4 % | Percentage activation of MCF-7-2a cells at 1 uM | ChEMBL. | 15658860 |
Activation (binding) | = 16 % | Percent activation of estrogen receptor alpha in luciferase assay at 10 uM | ChEMBL. | 15658860 |
Activation (binding) | = 16 % | Percent activation of estrogen receptor alpha in luciferase assay at 10 uM | ChEMBL. | 15658860 |
Activation (binding) | = 26 % | Percent activation of estrogen receptor beta in luciferase assay at 10 uM | ChEMBL. | 15658860 |
Activation (binding) | = 26 % | Percent activation of estrogen receptor beta in luciferase assay at 10 uM | ChEMBL. | 15658860 |
Inhibition (functional) | = 0 | Inhibition of 1 nM estradiol activity in MCF-7-2a cells | ChEMBL. | 15658860 |
Inhibition (functional) | = 0 % | Inhibition of 1 nM estradiol activity in MCF-7-2a cells | ChEMBL. | 15658860 |
Inhibition (binding) | = 3 % | Percent inhibition of 0.03 nM estradiol activity on estrogen receptor alpha in MCF-7-2a cells at 10 uM | ChEMBL. | 15658860 |
Inhibition (binding) | = 3 % | Percent inhibition of 0.03 nM estradiol activity on estrogen receptor alpha in MCF-7-2a cells at 10 uM | ChEMBL. | 15658860 |
Inhibition (binding) | = 12 % | Percent inhibition of 0.30 nM estradiol activity on estrogen receptor beta in MCF-7-2a cells at 10 uM | ChEMBL. | 15658860 |
Inhibition (binding) | = 12 % | Percent inhibition of 0.30 nM estradiol activity on estrogen receptor beta in MCF-7-2a cells at 10 uM | ChEMBL. | 15658860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.