Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.9 nM | Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-induced calcium flux | ChEMBL. | 21531136 |
IC50 (functional) | = 7.1 nM | Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-induced calcium flux | ChEMBL. | 21531136 |
IC50 (functional) | = 13 nM | Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization | ChEMBL. | 18299195 |
IC50 (functional) | = 13 nM | Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization | ChEMBL. | 18299195 |
IC50 (binding) | = 22 nM | Inhibition of binding to human vanilloid receptor subtype VR1 | ChEMBL. | 15689158 |
IC50 (binding) | = 22 nM | Inhibition of binding to human vanilloid receptor subtype VR1 | ChEMBL. | 15689158 |
IC50 (functional) | = 35 nM | Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization | ChEMBL. | 18299195 |
IC50 (functional) | = 35 nM | Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization | ChEMBL. | 18299195 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.