Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0289 | 1 | 1 | |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0251 | 0.8536 | 0.8536 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0047 | 0.0534 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0047 | 0.0534 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0047 | 0.0534 | 0.0872 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0047 | 0.0534 | 0.0872 |
Echinococcus granulosus | myotubularin protein 13 | 0.0039 | 0.0254 | 0.0414 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0047 | 0.0534 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0047 | 0.0534 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0047 | 0.0534 | 0.5 |
Brugia malayi | map kinase activated protein kinase protein 2 | 0.019 | 0.6129 | 0.6288 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0047 | 0.0534 | 0.0872 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.0534 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.0534 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0047 | 0.0534 | 0.0872 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.0534 | 0.0548 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0047 | 0.0534 | 0.5 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0047 | 0.0534 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.8462 | 0.8462 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0047 | 0.0534 | 0.0872 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.0534 | 0.5 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.019 | 0.6129 | 1 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0039 | 0.0254 | 0.0414 |
Brugia malayi | Protein kinase domain containing protein | 0.0047 | 0.0534 | 0.0548 |
Giardia lamblia | Kinase, CMGC CDK | 0.0047 | 0.0534 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0047 | 0.0534 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0254 | 0.0254 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0047 | 0.0534 | 0.0872 |
Onchocerca volvulus | 0.0281 | 0.9672 | 0.7864 | |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0047 | 0.0534 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0047 | 0.0534 | 0.5 |
Brugia malayi | C1-like domain containing protein | 0.0282 | 0.9746 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0047 | 0.0534 | 0.5 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.019 | 0.6129 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0047 | 0.0534 | 0.0872 |
Schistosoma mansoni | serine/threonine protein kinase | 0.019 | 0.6129 | 0.6288 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.9672 | 0.9672 |
Schistosoma mansoni | vav2 | 0.0039 | 0.0254 | 0.0261 |
Brugia malayi | Pleckstrin Homology Domain | 0.0039 | 0.0254 | 0.0261 |
Schistosoma mansoni | protein kinase C mu | 0.0282 | 0.9746 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0047 | 0.0534 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.0047 | 0.0534 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.046 | 0.046 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.8462 | 0.8462 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0047 | 0.0534 | 0.0534 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0047 | 0.0534 | 0.5 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0282 | 0.9746 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0047 | 0.0534 | 0.5 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.019 | 0.6129 | 0.6129 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.0534 | 0.0548 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0282 | 0.9746 | 0.9746 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0047 | 0.0534 | 0.5 |
Brugia malayi | cell division control protein 2 homolog | 0.0047 | 0.0534 | 0.0548 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0047 | 0.0534 | 0.0534 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.8 ug ml-1 | In vitro minimum inhibitory concentration against Candida tropicalis Berkout KCCM 50662 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | = 0.8 ug ml-1 | In vitro minimum inhibitory concentration against Aspergillus niger KCTC 1231 strain at 37 degree C after 2 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | = 6.3 ug ml-1 | In vitro minimum inhibitory concentration against Candida krusei Berkout KCCM 11655 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | = 50 ug ml-1 | In vitro minimum inhibitory concentration against Candida albicans Berkout KCCM 50235 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | = 50 ug ml-1 | In vitro minimum inhibitory concentration against Candida albicans Berkout KCCM 50235 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.