Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tissue type plasminogen activator | 0.0041 | 0.1801 | 0.4178 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0041 | 0.1801 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0041 | 0.1801 | 0.5 |
Brugia malayi | Fibroblast growth factor family protein | 0.0064 | 0.4255 | 0.4255 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0041 | 0.1801 | 0.4178 |
Brugia malayi | Fibroblast growth factor family protein | 0.0064 | 0.4255 | 0.4255 |
Echinococcus multilocularis | anti dorsalizing morphogenetic protein 1a | 0.0065 | 0.4312 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0041 | 0.1801 | 0.1801 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4255 | 0.4255 |
Loa Loa (eye worm) | bone morphogenic protein 6 | 0.0065 | 0.4312 | 0.4312 |
Giardia lamblia | Hypothetical protein | 0.0064 | 0.4255 | 0.5 |
Echinococcus granulosus | anti dorsalizing morphogenetic protein 1a | 0.0065 | 0.4312 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.1801 | 0.1801 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.1801 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1801 | 0.1801 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0041 | 0.1801 | 0.1801 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.1801 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.1801 | 1 | |
Toxoplasma gondii | kringle domain-containing protein | 0.0041 | 0.1801 | 0.5 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0065 | 0.4312 | 0.4312 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1801 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4255 | 0.4255 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (functional) | = 99 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 25 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 99 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 25 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 107 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 200 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 107 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 200 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 112 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 112 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 119 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 100 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 119 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 100 mg/kg i.p. | ChEMBL. | 7452684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.