Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.1127 | 0.3854 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0063 | 0.0137 | 0.0112 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2887 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2887 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0063 | 0.0137 | 0.0117 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1127 | 0.3854 | 0.3768 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0137 | 0.7668 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.0095 | 0.0075 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1127 | 0.3854 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1127 | 0.3854 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1127 | 0.3854 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0063 | 0.0137 | 0.0112 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1127 | 0.3854 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0061 | 0.0129 | 0.011 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0063 | 0.0137 | 0.0117 |
Loa Loa (eye worm) | glutamate receptor | 0.0061 | 0.0129 | 0.7241 |
Giardia lamblia | Histone deacetylase | 0.0063 | 0.0137 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2887 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0055 | 0.0109 | 0.009 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.1127 | 0.3854 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0063 | 0.0137 | 0.7668 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2887 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0063 | 0.0137 | 0.0112 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1127 | 0.3854 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.2887 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2887 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2887 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2887 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1127 | 0.3854 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1127 | 0.3854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0179 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0063 | 0.0137 | 0.0112 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0063 | 0.0137 | 0.7668 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2887 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.1127 | 0.3854 | 0.3841 |
Schistosoma mansoni | histone deacetylase | 0.0063 | 0.0137 | 0.0117 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0063 | 0.0137 | 0.0117 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0075 | 0.0179 | 0.0223 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2887 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2887 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0069 | 0.0159 | 0.0139 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1127 | 0.3854 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2887 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1127 | 0.3854 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0075 | 0.0179 | 0.0223 |
Brugia malayi | Histone deacetylase 1 | 0.0063 | 0.0137 | 0.0117 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2887 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2887 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1580 nM | Effective concentration against Metabotropic glutamate receptor 2 in [35S]-GTP-gammaS, binding assay | ChEMBL. | 15837331 |
Response (functional) | = 69 % | Potentiation of Metabotropic glutamate receptor 2 as percentage of maximum glutamate response at 1 mM | ChEMBL. | 15837331 |
Response (functional) | = 69 % | Potentiation of Metabotropic glutamate receptor 2 as percentage of maximum glutamate response at 1 mM | ChEMBL. | 15837331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.