Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenylate cyclase 9 | 0.0094 | 0 | 0.5 |
Brugia malayi | Adenylyl cyclase protein | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.976 | 1 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0094 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 17 % | Percent displacement of [3H]-CGS-21,680 binding to adenosine A2A receptors of bovine striatal membranes at 0.00005 M | ChEMBL. | 15743197 |
Displacement (binding) | = 20 % | Percent displacement of [125I]-AB-MECA binding to adenosine A3 receptors of bovine cortical membranes at 0.00005 M | ChEMBL. | 15743197 |
IC50 (binding) | = 4010 nM | Inhibition of adenylyl cyclase activity in rat cortical membranes | ChEMBL. | 15743197 |
Inhibition (binding) | = 21.8 % | Maximum percent inhibition of adenylyl cyclase activity in rat cortical membranes | ChEMBL. | 15743197 |
Ki (binding) | = 5370 nM | Displacement of [3H]-DPCPX binding to adenosine A1 receptors of bovine cortical membranes | ChEMBL. | 15743197 |
Ratio (binding) | > 1.9 | Relative affinities against adenosine A2A and A1 receptors (ratio of KiA2A/KiA1) | ChEMBL. | 15743197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.