Detailed information for compound 339173

Basic information

Technical information
  • TDR Targets ID: 339173
  • Name: N-[4-methyl-2-(4-pyrrolidin-1-ylpiperidin-1-y l)quinolin-6-yl]-2-[4-(trifluoromethoxy)pheno xy]acetamide
  • MW: 528.566 | Formula: C28H31F3N4O3
  • H donors: 1 H acceptors: 2 LogP: 6.15 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1ccc2c(c1)c(C)cc(n2)N1CCC(CC1)N1CCCC1)COc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C28H31F3N4O3/c1-19-16-26(35-14-10-21(11-15-35)34-12-2-3-13-34)33-25-9-4-20(17-24(19)25)32-27(36)18-37-22-5-7-23(8-6-22)38-28(29,30)31/h4-9,16-17,21H,2-3,10-15,18H2,1H3,(H,32,36)
  • InChiKey: ROIFDGZSVAMLHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-methyl-2-(4-pyrrolidin-1-yl-1-piperidyl)-6-quinolyl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
  • N-[4-methyl-2-[4-(1-pyrrolidinyl)-1-piperidinyl]-6-quinolyl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
  • N-[4-methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]ethanamide
  • N-[4-methyl-2-(4-pyrrolidinopiperidino)-6-quinolyl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
  • N-[4-methyl-2-(4-1-pyrrolidinyl-1-piperidinyl)-6-quinolyl]-2-[4-(trifluoromethoxy)phenoxy]acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 2 Starlite/ChEMBL References
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum dihydroorotate dehydrogenase 0.2307 0.5 0.5
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.2307 0.5 0.5
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2307 0.5 0.5
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2307 0.5 0.5
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.2307 0.5 0.5
Schistosoma mansoni dihydroorotate dehydrogenase 0.2307 0.5 0.5
Leishmania major dihydroorotate dehydrogenase 0.2307 0.5 0.5
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.2307 0.5 0.5
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.2307 0.5 0.5
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2307 0.5 0.5
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2307 0.5 0.5
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.2307 0.5 0.5
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.2307 0.5 0.5
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.2307 0.5 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.5 nM Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay ChEMBL. 16134937
IC50 (binding) = 1.5 nM Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay ChEMBL. 16134937
IC50 (binding) = 6.3 nM Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay ChEMBL. 16134937
IC50 (binding) = 6.3 nM Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay ChEMBL. 16134937
IC50 (binding) = 7.1 nM Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells ChEMBL. 16134937
IC50 (binding) = 7.1 nM Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells ChEMBL. 16134937
IC50 (functional) = 7.5 nM Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol ChEMBL. 16134937
IC50 (functional) = 7.5 nM Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol ChEMBL. 16134937

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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