Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.6645 | 0.6645 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0127 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.6673 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0109 | 0.8069 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.6673 | 0.0085 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.6673 | 0.6673 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.6673 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.6673 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.7127 | 0.7127 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.6673 | 0.0085 |
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.7127 | 0.1439 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.6673 | 0.6673 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.6673 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20.3 uM | Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reader analysis | ChEMBL. | 27089209 |
Inhibition (binding) | = 29 % | Inhibition [3H]-AMPA binding to ionotropic glutamate receptor AMPA in rat whole brain membranes in the presence of 100 microM KSCN | ChEMBL. | 8632440 |
Inhibition (binding) | = 29 % | Inhibition [3H]-AMPA binding to ionotropic glutamate receptor AMPA in rat whole brain membranes in the presence of 100 microM KSCN | ChEMBL. | 8632440 |
Ki (binding) | = -5.21 | In vitro binding affinity for glycine site on the NMDA receptor. | ChEMBL. | No reference |
Log Ki (binding) | = 5.21 | In vitro binding affinity for glycine site on the NMDA receptor. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.