Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.01 | 0.6138 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0078 | 0.3289 | 0.3289 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0085 | 0.4255 | 0.4255 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.013 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0085 | 0.4255 | 0.1439 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Binding stoichiometry (binding) | = 1.17 | Binding stoichiometry to TTR in human blood plasma determined by antibody capture/HPLC method | ChEMBL. | 15743199 |
Formation (binding) | = 4 % | Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM) | ChEMBL. | 15743199 |
Formation (binding) | = 4 % | Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM) | ChEMBL. | 15743199 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.