Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) | DNA polymerase | Starlite/ChEMBL | References |
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) | Human herpesvirus 5 DNA polymerase | Starlite/ChEMBL | References |
Herpes simplex virus (type 1 / strain 17) | Human herpesvirus 1 DNA polymerase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Toxicity of the compound on uninfected human foreskin fibroblast cells determined in microscopic evaluation and quantitative neutral red dye uptake assay | ChEMBL. | 16134946 |
CC50 (ADMET) | > 100 uM | Toxicity of the compound on uninfected African green monkey kidney cells determined in microscopic evaluation and quantitative neutral red dye uptake assay | ChEMBL. | 16134946 |
CC50 (ADMET) | > 100 uM | Toxicity of the compound on uninfected human foreskin fibroblast cells determined in microscopic evaluation and quantitative neutral red dye uptake assay | ChEMBL. | 16134946 |
IC50 (binding) | uM | Inhibition of varicella-zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C | ChEMBL. | 16134946 |
IC50 (binding) | uM | Inhibition of human gamma DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C ; nd is not determined | ChEMBL. | 16134946 |
IC50 (binding) | ND 0 uM | Inhibition of varicella-zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C | ChEMBL. | 16134946 |
IC50 (binding) | 0 uM | Inhibition of human gamma DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C ; nd is not determined | ChEMBL. | 16134946 |
IC50 (functional) | = 0.09 uM | Antiviral activity against varicella-zoster virus (Webster strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed | ChEMBL. | 16134946 |
IC50 (functional) | = 0.09 uM | Antiviral activity against varicella-zoster virus (Webster strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed | ChEMBL. | 16134946 |
IC50 (binding) | = 0.4 uM | Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C | ChEMBL. | 16134946 |
IC50 (binding) | = 0.4 uM | Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C | ChEMBL. | 16134946 |
IC50 (binding) | = 0.46 uM | Inhibition of varicella-zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C | ChEMBL. | 16134946 |
IC50 (binding) | = 0.46 uM | Inhibition of varicella-zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C | ChEMBL. | 16134946 |
IC50 (binding) | = 0.5 uM | Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C | ChEMBL. | 16134946 |
IC50 (binding) | = 0.5 uM | Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C | ChEMBL. | 16134946 |
IC50 (functional) | = 0.6 uM | Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO | ChEMBL. | 16134946 |
IC50 (functional) | = 0.6 uM | Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO | ChEMBL. | 16134946 |
IC50 (functional) | = 3 uM | Antiviral activity against herpes simplex virus type 1 (KOS strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed | ChEMBL. | 16134946 |
IC50 (binding) | > 40 uM | Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO | ChEMBL. | 16134946 |
IC50 (binding) | > 40 uM | Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO | ChEMBL. | 16134946 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16134946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.