Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 2.0486 | 0.5 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 2.0486 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 2.0486 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 2.0486 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 2.0486 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 ratio (functional) | = 0.2 | Antagonistic activity against Opioid receptor kappa 1 in guinea pig ileum assay | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 0.9 | Antagonistic activity against Opioid receptor mu 1 in guinea pig ileum assay | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 1.6 | Antagonistic activity against opioid delta receptor in mouse vas deferens after 10 minutes. Preparation was washed (5x) with buffer after incubation with antagonist. | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 3.1 | Antagonistic activity against opioid delta receptor in mouse vas deferens after 30 min incubation. Preparation was washed (5x) with buffer after incubation with antagonist. | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 7.1 | Tested in vivo for antagonistic activity against opioid delta receptor in mice at incubation time of 60 minutes. Preparation was washed (5x) with buffer after incubation with antagonist. | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 31 | Antagonistic activity against opioid delta receptor in mouse vas deferens after 30 min. IC50 ratio determined without washing (prewash). | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 0.2 | Antagonistic activity against Opioid receptor kappa 1 in guinea pig ileum assay | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 0.9 | Antagonistic activity against Opioid receptor mu 1 in guinea pig ileum assay | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 1.6 | Antagonistic activity against opioid delta receptor in mouse vas deferens after 10 minutes. Preparation was washed (5x) with buffer after incubation with antagonist. | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 3.1 | Antagonistic activity against opioid delta receptor in mouse vas deferens after 30 min incubation. Preparation was washed (5x) with buffer after incubation with antagonist. | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 7.1 | Tested in vivo for antagonistic activity against opioid delta receptor in mice at incubation time of 60 minutes. Preparation was washed (5x) with buffer after incubation with antagonist. | ChEMBL. | 7731019 |
IC50 ratio (functional) | = 31 | Antagonistic activity against opioid delta receptor in mouse vas deferens after 30 min. IC50 ratio determined without washing (prewash). | ChEMBL. | 7731019 |
Selectivity (functional) | = 31 | Selectivity ratio of the compound as the ratio of IC50 ratio of delta receptor to that of mu receptor. | ChEMBL. | 7731019 |
Selectivity (functional) | = 31 | Selectivity ratio of the compound as the ratio of IC50 ratio of delta receptor to that of kappa receptor. | ChEMBL. | 7731019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.