Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0296 | 0.0049 | 0.0049 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0296 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.026 | 0.0023 | 0.0014 |
Mycobacterium ulcerans | hydrolase | 0.5203 | 0.3609 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0766 | 0.039 | 0.0562 |
Brugia malayi | Hemopexin family protein | 0.4538 | 0.3126 | 0.5011 |
Echinococcus multilocularis | adam 17 protease | 0.0364 | 0.0098 | 0.0098 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.0014 | 0.0014 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0296 | 0.0049 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.5203 | 0.3609 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.4272 | 0.2933 | 0.4362 |
Onchocerca volvulus | 0.4538 | 0.3126 | 0.465 | |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0296 | 0.0049 | 0.0049 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0364 | 0.0098 | 0.0273 |
Brugia malayi | Matrixin family protein | 0.4272 | 0.2933 | 0.47 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 1.4014 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.881 | 0.6225 | 0.9279 |
Loa Loa (eye worm) | hypothetical protein | 0.4272 | 0.2933 | 0.4362 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0296 | 0.0049 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.9475 | 0.6708 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0941 | 0.0517 | 0.1616 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.026 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.5203 | 0.3609 | 0.537 |
Brugia malayi | Matrixin family protein | 0.4272 | 0.2933 | 0.47 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.0049 | 0.0053 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.4272 | 0.2933 | 0.4362 |
Brugia malayi | Matrixin family protein | 0.4272 | 0.2933 | 0.47 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.4272 | 0.2933 | 0.4362 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.0014 | 0.0014 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0296 | 0.0049 | 0.0114 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.4272 | 0.2933 | 0.4362 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.0014 | 0.0014 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.026 | 0.0023 | 0.0023 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.5203 | 0.3609 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.026 | 0.0023 | 0.0015 |
Brugia malayi | Matrixin family protein | 0.881 | 0.6225 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0296 | 0.0049 | 0.0049 |
Brugia malayi | Matrixin family protein | 0.4272 | 0.2933 | 0.47 |
Echinococcus granulosus | adam 17 protease | 0.0401 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | matrixin family protein | 0.9475 | 0.6708 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.4272 | 0.2933 | 0.938 |
Onchocerca volvulus | Matrilysin homolog | 0.9475 | 0.6708 | 1 |
Schistosoma mansoni | hypothetical protein | 0.4538 | 0.3126 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.5203 | 0.3609 | 0.5788 |
Onchocerca volvulus | 0.4272 | 0.2933 | 0.4362 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in baby hamster cells expressing human IBAT | ChEMBL. | 16134951 |
IC50 (binding) | = 2 nM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in baby hamster cells expressing human IBAT | ChEMBL. | 16134951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.