Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0176 | 0.6856 | 0.6856 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0147 | 0.5603 | 0.5603 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0247 | 1 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.6856 | 0.6856 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 1 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0247 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0176 | 0.6856 | 0.6856 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.6856 | 0.6856 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 1 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.01 | 0.3554 | 0.3554 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | In vitro inhibition of ASBT mediated uptake of [14C]-taurocholate (5 uM) in baby hamster cells expressing human IBAT | ChEMBL. | 16134951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.