Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Inhibition of 17-beta-hydroxysteroid dehydrogenase type 1 expressed in T47D human breast cancer cells using 2 nM [3H]-Estrone; b is not determined | ChEMBL. | 16134943 |
IC50 (binding) | 0 uM | Inhibition of 17-beta-hydroxysteroid dehydrogenase type 1 expressed in T47D human breast cancer cells using 2 nM [3H]-Estrone; b is not determined | ChEMBL. | 16134943 |
Inhibition (binding) | % | Inhibitory activity at 10 uM against 17-beta-hydroxysteroid dehydrogenase type 1 expressed in T47D human breast cancer cells using 2 nM [3H]-Estrone for 30 minutes; b is not determined | ChEMBL. | 16134943 |
Inhibition (binding) | % | Inhibitory activity at 10 uM against 17-beta-hydroxysteroid dehydrogenase type 2 in MDAMB-231 human breast cancer cells using 2 nM [3H]-Estradiol; b is not determined | ChEMBL. | 16134943 |
Inhibition (binding) | 0 % | Inhibitory activity at 10 uM against 17-beta-hydroxysteroid dehydrogenase type 1 expressed in T47D human breast cancer cells using 2 nM [3H]-Estrone for 30 minutes; b is not determined | ChEMBL. | 16134943 |
Inhibition (binding) | 0 % | Inhibitory activity at 10 uM against 17-beta-hydroxysteroid dehydrogenase type 2 in MDAMB-231 human breast cancer cells using 2 nM [3H]-Estradiol; b is not determined | ChEMBL. | 16134943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.