CC50 (ADMET)
|
> 100 uM
|
Toxicity of the compound on uninfected human foreskin fibroblast cells determined in microscopic evaluation and quantitative neutral red dye uptake assay
|
ChEMBL.
|
16134946
|
CC50 (ADMET)
|
> 100 uM
|
Toxicity of the compound on uninfected African green monkey kidney cells determined in microscopic evaluation and quantitative neutral red dye uptake assay
|
ChEMBL.
|
16134946
|
CC50 (ADMET)
|
> 100 uM
|
Toxicity of the compound on uninfected human foreskin fibroblast cells determined in microscopic evaluation and quantitative neutral red dye uptake assay
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
= 0.77 uM
|
Inhibition of varicella-zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 0.77 uM
|
Antiviral activity against varicella-zoster virus (Webster strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
= 0.77 uM
|
Inhibition of varicella-zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 0.77 uM
|
Antiviral activity against varicella-zoster virus (Webster strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 0.8 uM
|
Antiviral activity against herpes simplex virus type 1 KOS (PAAr5) plaque forming unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 0.8 uM
|
Antiviral activity against herpes simplex virus type 2 (WT) plaque formoing unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 0.8 uM
|
Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 0.8 uM
|
Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
= 1.1 uM
|
Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
= 1.1 uM
|
Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
= 1.2 uM
|
Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
= 1.2 uM
|
Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 1.5 uM
|
Antiviral activity against human cytomegalovirus Ad169 (WT) plaque formoing unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 1.5 uM
|
Antiviral activity against human cytomegalovirus Ad169 (WT) plaque formoing unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 2.1 uM
|
Antiviral activity against herpes simplex virus type 1 KOS (AraAr13) plaque forming unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 2.5 uM
|
Antiviral activity against herpes simplex virus type 1 KOS (PFAr2) plaque forming unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 2.5 uM
|
Antiviral activity against herpes simplex virus type 1 Patton(BWr) plaque forming unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 3.7 uM
|
Antiviral activity against herpes simplex virus type 1 (KOS strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 5.4 uM
|
Antiviral activity against herpes simplex virus type 1 Patton (WT) plaque forming unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 5.6 uM
|
Antiviral activity against herpes simplex virus type 1 KOS (WT) plaque formoing unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 6.2 uM
|
Antiviral activity against human cytomegalovirus Ad169 (V823A) plaque formoing unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
= 6.2 uM
|
Antiviral activity against human cytomegalovirus Ad169 (V823A) plaque formoing unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
> 40 uM
|
Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
> 40 uM
|
Inhibition of varicella-zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
> 40 uM
|
Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
> 40 uM
|
Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
> 40 uM
|
Inhibition of varicella-zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
|
ChEMBL.
|
16134946
|
IC50 (binding)
|
> 40 uM
|
Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
> 50 uM
|
Antiviral activity against herpes simplex virus type 1 KOS (V823A) plaque forming unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|
IC50 (functional)
|
> 50 uM
|
Antiviral activity against herpes simplex virus type 2 (V826A) plaque formoing unit grown on Human foreskin fibroblast cells upon incubation for 1 hour at 37 degrees C with compound dissolved in DMSO
|
ChEMBL.
|
16134946
|